biostudies-literatureUnknown27(23)Xu ZZhihong Xu professional development funds from Augustana UniversityNatural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products are also included. Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.Molecules (Basel, Switzerland)8280https://www.ebi.ac.uk/biostudies/studies/S-EPMC9736696biostudies-literatureLead/Drug Discovery from Natural Resources.PMC9736696Klausner EADuffy-Matzner JZheng WEichler BXu ZfalseLead/Drug Discovery from Natural Resources.Natural products and their derivatives have been shown to be effective drug candidates against various diseases for many years. Over a long period of time, nature has produced an abundant and prosperous source pool for novel therapeutic agents with distinctive structures. Major natural-product-based drugs approved for clinical use include anti-infectives and anticancer agents. This paper will review some natural-product-related potent anticancer, anti-HIV, antibacterial and antimalarial drugs or lead compounds mainly discovered from 2016 to 2022. Structurally typical marine bioactive products are also included. Molecular modeling, machine learning, bioinformatics and other computer-assisted techniques that are very important in narrowing down bioactive core structural scaffolds and helping to design new structures to fight against key disease-associated molecular targets based on available natural products are considered and briefly reviewed.2022-01-01T00:00:00Z2022 Nov2024-11-14T17:42:04.58Z2024-11-14T17:42:04.58ZS-EPMC97366963650037510.3390/molecules27238280