biostudies-literatureHuang JGuangxi Science and Technology Base Special Talentsthe Natural Science Foundation of Guangxi ProvinceNational Natural Science Foundation of ChinaDepartment of Science and Technology of Guangzhou8160https://www.ebi.ac.uk/biostudies/studies/S-EPMC9737011biostudies-literatureUnknown27(23)Chemical investigation of the fermentation extract of the mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-A1, isolated from <i>Acanthus ilicifolius</i> L., discovered an undescribed pair of enantiomers (asperphenyltones A and B (<b>±1</b>)), together with four previously described metabolites: nodulisporol (<b>2</b>), isosclerone (<b>3</b>), 2,3,4-trihydroxy-6-(hydroxymethyl)-5-methylbenzyl alcohol (<b>4</b>), and 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (<b>5</b>). Analyses of the 1D and 2D NMR spectroscopic data of the compounds supported their structural assignments. The presence of the asperphenyltones A and B, which are a pair of enantiomers, was established by HR-ESI-MS, 1D and 2D NMR data and confirmed by single-crystal X-ray diffraction analysis. MetabolitesMolecules (Basel, Switzerland)Asperphenyltones A and B: New Phenylfuropyridinone Skeleton from an Endophytic <i>Aspergillus</i> sp. GXNU-A1.PMC97370112020JJA1500362021020206082019AC2009542066005Tan MHuang JHuang XBo XWu GWu FWei YWang LZhou JfalseAsperphenyltones A and B: New Phenylfuropyridinone Skeleton from an Endophytic <i>Aspergillus</i> sp. GXNU-A1.Chemical investigation of the fermentation extract of the mangrove endophytic fungus <i>Aspergillus</i> sp. GXNU-A1, isolated from <i>Acanthus ilicifolius</i> L., discovered an undescribed pair of enantiomers (asperphenyltones A and B (<b>±1</b>)), together with four previously described metabolites: nodulisporol (<b>2</b>), isosclerone (<b>3</b>), 2,3,4-trihydroxy-6-(hydroxymethyl)-5-methylbenzyl alcohol (<b>4</b>), and 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (<b>5</b>). Analyses of the 1D and 2D NMR spectroscopic data of the compounds supported their structural assignments. The presence of the asperphenyltones A and B, which are a pair of enantiomers, was established by HR-ESI-MS, 1D and 2D NMR data and confirmed by single-crystal X-ray diffraction analysis. Metabolites2022-01-01T00:00:00Z2022 Nov2026-04-08T11:54:09.4Z2024-11-15T04:20:27.063ZS-EPMC97370113650025210.3390/molecules27238160