biostudies-literatureUnknown23(23)Casas-Aparicio GIn hospitalized COVID-19 patients, disease progression leading to acute kidney injury (AKI) may be driven by immune dysregulation. We explored the role of urinary cytokines and their relationship with kidney stress biomarkers in COVID-19 patients before and after the development of AKI. Of 51 patients, 54.9% developed AKI. The principal component analysis indicated that in subclinical AKI, epidermal growth factor (EGF) and interferon (IFN)-α were associated with a lower risk of AKI, while interleukin-12 (IL-12) and macrophage inflammatory protein (MIP)-1β were associated with a higher risk of AKI. After the manifestation of AKI, EGF and IFN-α remained associated with a lower risk of AKI, while IL-1 receptor (IL-1R), granulocyte-colony stimulating factor (G-CSF), interferon-gamma-inducible International journal of molecular sciences15419https://www.ebi.ac.uk/biostudies/studies/S-EPMC9737068biostudies-literatureLongitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury.PMC9737068Calderon-Davila NOlmedo-Ocampo RLuna-Villalobos YPiekarska KAvila-Rios SJuarez-Diaz ALeon-Rodriguez IFigueroa-Hernandez LEscamilla-Illescas DGonzalez-Navarro MPiten-Isidro EPeralta-Prado ABAlvarado-de la Barrera CCasas-Aparicio GCastillejos-Lopez MFernandez-Campos PDel Rio-Estrada PMfalseLongitudinal Analysis of Urinary Cytokines and Biomarkers in COVID-19 Patients with Subclinical Acute Kidney Injury.In hospitalized COVID-19 patients, disease progression leading to acute kidney injury (AKI) may be driven by immune dysregulation. We explored the role of urinary cytokines and their relationship with kidney stress biomarkers in COVID-19 patients before and after the development of AKI. Of 51 patients, 54.9% developed AKI. The principal component analysis indicated that in subclinical AKI, epidermal growth factor (EGF) and interferon (IFN)-α were associated with a lower risk of AKI, while interleukin-12 (IL-12) and macrophage inflammatory protein (MIP)-1β were associated with a higher risk of AKI. After the manifestation of AKI, EGF and IFN-α remained associated with a lower risk of AKI, while IL-1 receptor (IL-1R), granulocyte-colony stimulating factor (G-CSF), interferon-gamma-inducible 2022-01-01T00:00:00Z2022 Dec2025-04-20T03:33:32.637Z2025-04-20T03:33:32.637ZS-EPMC97370683649974510.3390/ijms232315419