biostudies-literatureSkeith LAnesthesia Academic CouncilNHLBI NIH HHSResearch Funds of Timothy7115https://www.ebi.ac.uk/biostudies/studies/S-EPMC9737388biostudies-literatureUnknown11(23)<h4>Background</h4>Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare disorder caused by an inherited genetic deficiency of ADAMTS13 and affects less than one per million individuals. Patients who are diagnosed with TTP during pregnancy are at increased risk of maternal and fetal complications including fetal demise. We present a case of a 32-year-old G3P0 (gravida 3, para 0) who presented at 20 weeks gestation with a new diagnosis of congenital TTP (cTTP) and fetal demise.<h4>Methods</h4>We describe the pathophysiology of pregnancy complications in a patient with cTTP using platelet procoagulant membrane dynamics analysis and quantitative proteomic studies, compared to four pregnant patients with gestational hypertension, four pregnant patients with preeclampsia, and four heaJournal of clinical medicineHypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise.PMC9737388K99 HL150594Soucie JNicholas JDufour ALee AYoung DHurd KGirard LAgbani EOChaturvedi SChow LGoodyear DSkeith LfalseHypercoagulability and Inflammatory Markers in a Case of Congenital Thrombotic Thrombocytopenic Purpura Complicated by Fetal Demise.<h4>Background</h4>Congenital thrombotic thrombocytopenic purpura (cTTP) is a rare disorder caused by an inherited genetic deficiency of ADAMTS13 and affects less than one per million individuals. Patients who are diagnosed with TTP during pregnancy are at increased risk of maternal and fetal complications including fetal demise. We present a case of a 32-year-old G3P0 (gravida 3, para 0) who presented at 20 weeks gestation with a new diagnosis of congenital TTP (cTTP) and fetal demise.<h4>Methods</h4>We describe the pathophysiology of pregnancy complications in a patient with cTTP using platelet procoagulant membrane dynamics analysis and quantitative proteomic studies, compared to four pregnant patients with gestational hypertension, four pregnant patients with preeclampsia, and four hea2022-01-01T00:00:00Z2022 Nov2025-05-18T13:42:16.729Z2025-05-18T13:42:16.729ZS-EPMC97373883649868810.3390/jcm11237115