{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["23(23)"],"submitter":["Burilov V"],"pubmed_abstract":["Artificial gene delivery systems are in great demand from both scientific and practical biomedical points of view. In this paper, we present the synthesis of a new click chemistry calix[4]arene precursor with free lower rim and new water-soluble calixarene triazoles with 12 amino-groups on the upper rim (one with free phenol hydroxyl groups and two another containing four butyl or tetradecyl fragments). Aggregation in the series of amino-triazole calixarenes of different lipophilicity (calixarene with free phenol hydroxyl groups or butyl and tetradecyl fragments on the lower rim) was studied using dynamic light scattering and fluorescent pyrene probe. It was found that calix[4]arene with a free lower rim, like alkyl-substituted butyl calix[4]arene, forms stable submicron aggregates 150-200"],"journal":["International journal of molecular sciences"],"pagination":["14889"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9738031"],"repository":["biostudies-literature"],"pubmed_title":["Calix[4]arene Polyamine Triazoles: Synthesis, Aggregation and DNA Binding."],"pmcid":["PMC9738031"],"pubmed_authors":["Solovieva S","Antipin I","Usachev K","Mironova D","Makarov E","Burilov V","Sultanova E","Evtugyn V","Bilyukova I","Mukhametzyanov T","Akyol K","Islamov D"],"additional_accession":[]},"is_claimable":false,"name":"Calix[4]arene Polyamine Triazoles: Synthesis, Aggregation and DNA Binding.","description":"Artificial gene delivery systems are in great demand from both scientific and practical biomedical points of view. In this paper, we present the synthesis of a new click chemistry calix[4]arene precursor with free lower rim and new water-soluble calixarene triazoles with 12 amino-groups on the upper rim (one with free phenol hydroxyl groups and two another containing four butyl or tetradecyl fragments). Aggregation in the series of amino-triazole calixarenes of different lipophilicity (calixarene with free phenol hydroxyl groups or butyl and tetradecyl fragments on the lower rim) was studied using dynamic light scattering and fluorescent pyrene probe. It was found that calix[4]arene with a free lower rim, like alkyl-substituted butyl calix[4]arene, forms stable submicron aggregates 150-200","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-20T03:34:57.808Z","creation":"2025-04-20T03:34:57.808Z"},"accession":"S-EPMC9738031","cross_references":{"pubmed":["36499212"],"doi":["10.3390/ijms232314889"]}}