{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(23)"],"submitter":["Morlacci V"],"pubmed_abstract":["An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-N-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations."],"journal":["Molecules (Basel, Switzerland)"],"pagination":["8199"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9738245"],"repository":["biostudies-literature"],"pubmed_title":["Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of N-Aryl Isoindolinones."],"pmcid":["PMC9738245"],"pubmed_authors":["Palombi L","Aschi M","Morlacci V","Caruso T","Chiarini M","Arcadi A"],"additional_accession":[]},"is_claimable":false,"name":"Electrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of N-Aryl Isoindolinones.","description":"An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-N-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-20T03:30:43.974Z","creation":"2025-04-20T03:30:43.974Z"},"accession":"S-EPMC9738245","cross_references":{"pubmed":["36500288"],"doi":["10.3390/molecules27238199"]}}