biostudies-literatureUnknown27(23)Morlacci VAn electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-N-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations.Molecules (Basel, Switzerland)8199https://www.ebi.ac.uk/biostudies/studies/S-EPMC9738245biostudies-literatureElectrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of N-Aryl Isoindolinones.PMC9738245Palombi LAschi MMorlacci VCaruso TChiarini MArcadi AfalseElectrochemical-Induced Cascade Reaction of 2-Formyl Benzonitrile with Anilines: Synthesis of N-Aryl Isoindolinones.An electrochemical initiated tandem reaction of anilines with 2-formyl benzonitrile has been developed. Thus, unprecedented 3-N-aryl substituted isoindolinones have been conveniently achieved by constant current electrolysis in a divided cell using catalytic amount of electricity and supporting electrolyte and a Pt-cathode as working electrode. The origin of the electrochemical activation as well as the mechanism of the subsequent chemical cascade reactions have been investigated by DFT calculations.2022-01-01T00:00:00Z2022 Nov2025-04-20T03:30:43.974Z2025-04-20T03:30:43.974ZS-EPMC97382453650028810.3390/molecules27238199