{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu F"],"funding":["Jilin Provincial Department of Science and Technology","Jilin Province Science and Technology Department"],"pagination":["8346"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9738265"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(23)"],"pubmed_abstract":["Ulcerative colitis (UC) is a chronic, nonspecific inflammation of the bowel that mainly affects the mucosa and submucosa of the rectum and colon. Ginsenosides are the main active ingredients in ginseng and show many therapeutic effects in anti-inflammatory diseases, cancer, and nervous system regulation. Protopanaxatriol saponin (PTS) is an important part of saponins, and there is no research on its pharmacological effects on colitis. In this study, a model of ulcerative colitis in mice was induced by having mice freely drink 3.5% dextran sodium sulfate (DSS) solution, and UPLC-Q-TOF-MS-based metabolomics methods were applied to explore the therapeutic effect and protective mechanism of PTS for treating UC. The results showed that PTS could significantly prevent colon shortening and pathol"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Protective Effects of Protopanaxatriol Saponins on Ulcerative Colitis in Mouse Based on UPLC-Q/TOF-MS Serum and Colon Metabolomics."],"pmcid":["PMC9738265"],"funding_grant_id":["20220204025YY","20200504006YY"],"pubmed_authors":["Liu J","Fu D","Li Z","Feng H","Wang C","Li P","Lai S","Wu F"],"additional_accession":[]},"is_claimable":false,"name":"Protective Effects of Protopanaxatriol Saponins on Ulcerative Colitis in Mouse Based on UPLC-Q/TOF-MS Serum and Colon Metabolomics.","description":"Ulcerative colitis (UC) is a chronic, nonspecific inflammation of the bowel that mainly affects the mucosa and submucosa of the rectum and colon. Ginsenosides are the main active ingredients in ginseng and show many therapeutic effects in anti-inflammatory diseases, cancer, and nervous system regulation. Protopanaxatriol saponin (PTS) is an important part of saponins, and there is no research on its pharmacological effects on colitis. In this study, a model of ulcerative colitis in mice was induced by having mice freely drink 3.5% dextran sodium sulfate (DSS) solution, and UPLC-Q-TOF-MS-based metabolomics methods were applied to explore the therapeutic effect and protective mechanism of PTS for treating UC. The results showed that PTS could significantly prevent colon shortening and pathol","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-20T03:22:33.823Z","creation":"2025-04-20T03:36:17.119Z"},"accession":"S-EPMC9738265","cross_references":{"pubmed":["36500439"],"doi":["10.3390/molecules27238346"]}}