{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Slighoua M"],"funding":["Princess Nourah bint Abdulrahman University"],"pagination":["3222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9738568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(23)"],"pubmed_abstract":["We earlier emphasized in vivo the lavender plant's (<i>Lavandula officinalis</i> Chaix.) anti-inflammatory and estrogenic activities and described the chemical compositions of its hydro-ethanolic (HE) extract. We used LC-MS/MS and GC-MS analyses to profile the phytochemical composition of the HE extract and to assess the analgesic and wound-healing effects of both the hydro-ethanolic (HE) and polyphenolic (LOP) extracts in vivo and in silico. The analgesic activity was studied using two methods: acetic acid and formalin injections in mice. The wound-healing activity was carried out over 25 days using a burn model in rats. In the in silico study, the polyphenols identified in the plant were docked in the active sites of three enzymes: casein kinase-1, cyclooxygenase-2, and glycogen synthase"],"journal":["Plants (Basel, Switzerland)"],"pubmed_title":["The LC-MS/MS Identification and Analgesic and Wound Healing Activities of <i>Lavandula officinalis</i> Chaix: In Vivo and In Silico Approaches."],"pmcid":["PMC9738568"],"funding_grant_id":["PNURSP2022R147"],"pubmed_authors":["Amrati FE","Slighoua M","Chebaibi M","Alotaibi A","Saghrouchni H","Zair T","Conte R","Bari A","Mahdi I","Cordero MAW","Agour A","Bousta D"],"additional_accession":[]},"is_claimable":false,"name":"The LC-MS/MS Identification and Analgesic and Wound Healing Activities of <i>Lavandula officinalis</i> Chaix: In Vivo and In Silico Approaches.","description":"We earlier emphasized in vivo the lavender plant's (<i>Lavandula officinalis</i> Chaix.) anti-inflammatory and estrogenic activities and described the chemical compositions of its hydro-ethanolic (HE) extract. We used LC-MS/MS and GC-MS analyses to profile the phytochemical composition of the HE extract and to assess the analgesic and wound-healing effects of both the hydro-ethanolic (HE) and polyphenolic (LOP) extracts in vivo and in silico. The analgesic activity was studied using two methods: acetic acid and formalin injections in mice. The wound-healing activity was carried out over 25 days using a burn model in rats. In the in silico study, the polyphenols identified in the plant were docked in the active sites of three enzymes: casein kinase-1, cyclooxygenase-2, and glycogen synthase","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T08:00:56.037Z","creation":"2024-10-18T13:14:00.141Z"},"accession":"S-EPMC9738568","cross_references":{"pubmed":["36501262"],"doi":["10.3390/plants11233222"]}}