biostudies-literatureSlighoua MPrincess Nourah bint Abdulrahman University3222https://www.ebi.ac.uk/biostudies/studies/S-EPMC9738568biostudies-literatureUnknown11(23)We earlier emphasized in vivo the lavender plant's (<i>Lavandula officinalis</i> Chaix.) anti-inflammatory and estrogenic activities and described the chemical compositions of its hydro-ethanolic (HE) extract. We used LC-MS/MS and GC-MS analyses to profile the phytochemical composition of the HE extract and to assess the analgesic and wound-healing effects of both the hydro-ethanolic (HE) and polyphenolic (LOP) extracts in vivo and in silico. The analgesic activity was studied using two methods: acetic acid and formalin injections in mice. The wound-healing activity was carried out over 25 days using a burn model in rats. In the in silico study, the polyphenols identified in the plant were docked in the active sites of three enzymes: casein kinase-1, cyclooxygenase-2, and glycogen synthasePlants (Basel, Switzerland)The LC-MS/MS Identification and Analgesic and Wound Healing Activities of <i>Lavandula officinalis</i> Chaix: In Vivo and In Silico Approaches.PMC9738568PNURSP2022R147Amrati FESlighoua MChebaibi MAlotaibi ASaghrouchni HZair TConte RBari AMahdi ICordero MAWAgour ABousta DfalseThe LC-MS/MS Identification and Analgesic and Wound Healing Activities of <i>Lavandula officinalis</i> Chaix: In Vivo and In Silico Approaches.We earlier emphasized in vivo the lavender plant's (<i>Lavandula officinalis</i> Chaix.) anti-inflammatory and estrogenic activities and described the chemical compositions of its hydro-ethanolic (HE) extract. We used LC-MS/MS and GC-MS analyses to profile the phytochemical composition of the HE extract and to assess the analgesic and wound-healing effects of both the hydro-ethanolic (HE) and polyphenolic (LOP) extracts in vivo and in silico. The analgesic activity was studied using two methods: acetic acid and formalin injections in mice. The wound-healing activity was carried out over 25 days using a burn model in rats. In the in silico study, the polyphenols identified in the plant were docked in the active sites of three enzymes: casein kinase-1, cyclooxygenase-2, and glycogen synthase2022-01-01T00:00:00Z2022 Nov2025-04-04T08:00:56.037Z2024-10-18T13:14:00.141ZS-EPMC97385683650126210.3390/plants11233222