{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Geraghty NJ"],"funding":["Motor Neurone Disease Australia"],"pagination":["3907"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9738919"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(23)"],"pubmed_abstract":["The immune system is essential to protect organisms from internal and external threats. The rapidly acting, non-specific innate immune system includes complement, which initiates an inflammatory cascade and can form pores in the membranes of target cells to induce cell lysis. Regulation of protein homeostasis (proteostasis) is essential for normal cellular and organismal function, and has been implicated in processes controlling immunity and infection. Chaperones are key players in maintaining proteostasis in both the intra- and extracellular environments. Whilst intracellular proteostasis is well-characterised, the role of constitutively secreted extracellular chaperones (ECs) is less well understood. ECs may interact with invading pathogens, and elements of the subsequent immune response"],"journal":["Cells"],"pubmed_title":["The Emerging Roles of Extracellular Chaperones in Complement Regulation."],"pmcid":["PMC9738919"],"funding_grant_id":["PDF2104"],"pubmed_authors":["Wilson MR","Satapathy S","Geraghty NJ"],"additional_accession":[]},"is_claimable":false,"name":"The Emerging Roles of Extracellular Chaperones in Complement Regulation.","description":"The immune system is essential to protect organisms from internal and external threats. The rapidly acting, non-specific innate immune system includes complement, which initiates an inflammatory cascade and can form pores in the membranes of target cells to induce cell lysis. Regulation of protein homeostasis (proteostasis) is essential for normal cellular and organismal function, and has been implicated in processes controlling immunity and infection. Chaperones are key players in maintaining proteostasis in both the intra- and extracellular environments. Whilst intracellular proteostasis is well-characterised, the role of constitutively secreted extracellular chaperones (ECs) is less well understood. ECs may interact with invading pathogens, and elements of the subsequent immune response","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:00:51.493Z","creation":"2025-04-04T08:00:51.493Z"},"accession":"S-EPMC9738919","cross_references":{"pubmed":["36497163"],"doi":["10.3390/cells11233907"]}}