biostudies-literatureSantos SAASão Paulo Research FoundationNational Council for Scientific and Technological Development14855https://www.ebi.ac.uk/biostudies/studies/S-EPMC9739077biostudies-literatureUnknown23(23)The Developmental Origins of Health and Disease (DOHaD) concept correlates early life exposure to stressor conditions with the increased incidence of non-communicable chronic diseases, including prostate cancer (PCa), throughout the life span. However, the molecular mechanisms involved in this process remain poorly understood. In this study, the deregulation of two miRNAs (rno-miR-18a-5p and rno-miR-345-3p) was described in the ventral prostate VP of old rats born to dams fed with a low protein diet (LPD) (6% protein in the diet) during gestational and lactational periods. Integrative analysis of the (VP) transcriptomic and proteomic data revealed changes in the expression profile of 14 identified predicted targets of these two DE miRNAs, which enriched terms related to post-translational International journal of molecular sciencesmiR-18a-5p Is Involved in the Developmental Origin of Prostate Cancer in Maternally Malnourished Offspring Rats: A DOHaD Approach.PMC9739077CNPq grant # 310663/ 2018- 02019/03121-02017/01063-72017/25198-9310663/2018-0Zambrano EFioretto MNPortela LMFFelisbino SLSantos SAACamargo ACLPiazza SConstantino FBMattos Rde Almeida Fantinatti BEJustulin LAColombelli KTDenti MAfalsemiR-18a-5p Is Involved in the Developmental Origin of Prostate Cancer in Maternally Malnourished Offspring Rats: A DOHaD Approach.The Developmental Origins of Health and Disease (DOHaD) concept correlates early life exposure to stressor conditions with the increased incidence of non-communicable chronic diseases, including prostate cancer (PCa), throughout the life span. However, the molecular mechanisms involved in this process remain poorly understood. In this study, the deregulation of two miRNAs (rno-miR-18a-5p and rno-miR-345-3p) was described in the ventral prostate VP of old rats born to dams fed with a low protein diet (LPD) (6% protein in the diet) during gestational and lactational periods. Integrative analysis of the (VP) transcriptomic and proteomic data revealed changes in the expression profile of 14 identified predicted targets of these two DE miRNAs, which enriched terms related to post-translational 2022-01-01T00:00:00Z2022 Nov2026-06-20T03:12:09.76Z2024-11-13T21:52:10.879ZS-EPMC97390773649918310.3390/ijms232314855