{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Stilma W"],"funding":["Dutch Research Council (NWO)","NWO Netherlands Organisation for Scientific Research"],"pagination":["6988"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9739110"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(23)"],"pubmed_abstract":["We describe the incidence, practice and associations with outcomes of awake prone positioning in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) in a national multicenter observational cohort study performed in 16 intensive care units in the Netherlands (PRoAcT−COVID-study). Patients were categorized in two groups, based on received treatment of awake prone positioning. The primary endpoint was practice of prone positioning. Secondary endpoint was ‘treatment failure’, a composite of intubation for invasive ventilation and death before day 28. We used propensity matching to control for observed confounding factors. In 546 patients, awake prone positioning was used in 88 (16.1%) patients. Prone positioning started within median 1 (0 to 2) days after ICU admission, sessions summed up to median 12.0 (8.4−14.5) hours for median 1.0 day. In the unmatched analysis (HR, 1.80 (1.41−2.31); p < 0.001), but not in the matched analysis (HR, 1.17 (0.87−1.59); p = 0.30), treatment failure occurred more often in patients that received prone positioning. The findings of this study are that awake prone positioning was used in one in six COVID-19 patients. Prone positioning started early, and sessions lasted long but were often discontinued because of need for intubation."],"journal":["Journal of clinical medicine"],"pubmed_title":["Practice of Awake Prone Positioning in Critically Ill COVID-19 Patients-Insights from the PRoAcT-COVID Study."],"pmcid":["PMC9739110"],"funding_grant_id":["023.011.016"],"pubmed_authors":["Offermans M","Bevers M","Remmelzwaal D","Hansen HJ","Martin–Loeches I","Rezaee AS","van der Heiden PL","Stilma W","PRoAcT–COVID Collaborative Group","Vermeulen TD","Artigas A","Pillay J","Dongelmans DA","de Graaff MJ","Morales L","Kuiper MA","Koornstra E","van Oosten P","van Vliet P","Neto AS","van der Ven WH","Schultz MJ","van der Ven FL","Juffermans NP","Boers LS","Bergmans DC","Aydeniz E","Spronk PE","Haringman JJ","Valk CMA","Horn J","den Boer S","Sleeswijk ME","Rosenberg NM","Girbes AR","van de Berg P","van Meenen DMP","van Zanten AR","Buiteman-Kruizinga LA","Go DM","Hol L","Tuinman PR","Zandvliet JM","Yaali N","Mazzinari G","van Velzen P","Pisters T","Purmer IM","Vlaar AP","Paulus F","Di Leo V","van Zijl TZ","Rettig TCD","Roca O","Voorham JJJS","Nijbroek GSLH","Sciascera AA","Dormans TP","Prins A","Verhoef EJ","Kuipers LJ","Botta M","Lokhorst A","van der Voort PH","Elting LM","Esmeijer AA","van Ingen LE","Delmte M","Myatra SN","Weiner N","Coene W","Sherstha G","Tsonas AM","Gama de Abreu M","Bos LDJ","Goossen RL","Serpa Neto A","Zonneveld SA","Schavemaker N","Hollmann MW","Strang AC","Verboom M"],"additional_accession":[]},"is_claimable":false,"name":"Practice of Awake Prone Positioning in Critically Ill COVID-19 Patients-Insights from the PRoAcT-COVID Study.","description":"We describe the incidence, practice and associations with outcomes of awake prone positioning in patients with acute hypoxemic respiratory failure due to coronavirus disease 2019 (COVID-19) in a national multicenter observational cohort study performed in 16 intensive care units in the Netherlands (PRoAcT−COVID-study). Patients were categorized in two groups, based on received treatment of awake prone positioning. The primary endpoint was practice of prone positioning. Secondary endpoint was ‘treatment failure’, a composite of intubation for invasive ventilation and death before day 28. We used propensity matching to control for observed confounding factors. In 546 patients, awake prone positioning was used in 88 (16.1%) patients. Prone positioning started within median 1 (0 to 2) days after ICU admission, sessions summed up to median 12.0 (8.4−14.5) hours for median 1.0 day. In the unmatched analysis (HR, 1.80 (1.41−2.31); p < 0.001), but not in the matched analysis (HR, 1.17 (0.87−1.59); p = 0.30), treatment failure occurred more often in patients that received prone positioning. The findings of this study are that awake prone positioning was used in one in six COVID-19 patients. Prone positioning started early, and sessions lasted long but were often discontinued because of need for intubation.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-04-08T14:25:55.587Z","creation":"2025-04-04T23:37:07.725Z"},"accession":"S-EPMC9739110","cross_references":{"pubmed":["36498564"],"doi":["10.3390/jcm11236988"]}}