biostudies-literatureKiselev IRussian Science Foundation15280https://www.ebi.ac.uk/biostudies/studies/S-EPMC9739701biostudies-literatureUnknown23(23)Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease; its pathogenesis is still being intensively studied to explain the reasons for the significant genetic and phenotypic heterogeneity of the disease. To search for new genes involved in HCM development, we analyzed gene expression profiles coupled with DNA methylation profiles in the hypertrophied myocardia of HCM patients. The transcriptome analysis identified significant differences in the levels of 193 genes, most of which were underexpressed in HCM. The methylome analysis revealed 1755 nominally significant differentially methylated positions (DMPs), mostly hypomethylated in HCM. Based on gene ontology enrichment analysis, the majority of biological processes, overrepresented by both differentially expressed geInternational journal of molecular sciencesNovel Genes Involved in Hypertrophic Cardiomyopathy: Data of Transcriptome and Methylome Profiling.PMC973970120-15-00353Baulina NZotov AFavorova OKiselev IPisklova MDanilova LKozin MZateyshchikov DChumakova OfalseNovel Genes Involved in Hypertrophic Cardiomyopathy: Data of Transcriptome and Methylome Profiling.Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease; its pathogenesis is still being intensively studied to explain the reasons for the significant genetic and phenotypic heterogeneity of the disease. To search for new genes involved in HCM development, we analyzed gene expression profiles coupled with DNA methylation profiles in the hypertrophied myocardia of HCM patients. The transcriptome analysis identified significant differences in the levels of 193 genes, most of which were underexpressed in HCM. The methylome analysis revealed 1755 nominally significant differentially methylated positions (DMPs), mostly hypomethylated in HCM. Based on gene ontology enrichment analysis, the majority of biological processes, overrepresented by both differentially expressed ge2022-01-01T00:00:00Z2022 Dec2026-04-08T11:32:08.615Z2025-04-04T23:36:38.721ZS-EPMC97397013649960710.3390/ijms232315280