{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Radulovic NS"],"funding":["Ministry of Education, Science and Technological Development of the Republic of Serbia"],"pagination":["3340"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9739903"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(23)"],"pubmed_abstract":["Motivated by the ethnopharmacological use of <i>Pulicaria dysenterica</i>, in the present study, the antimicrobial potential of the extracted essential oil was investigated against a panel of eighteen microorganism strains. Additionally, anti-acetylcholinesterase and antispasmodic (isolated rat distal colon) activities, general acute toxicity (<i>Artemia salina</i> model), and immunomodulatory properties (cytotoxicity on isolated mouse macrophages) were studied. Detailed analyses of the essential oil led to the identification of 3-methoxycuminyl 2-methylbutanoate (a new natural product) and 3-methoxycuminyl 3-methylbutanoate (a rare natural product). The obtained esters and intermediates in the synthesis of the starting alcohol (3-methoxycuminol) were subjected to a battery of 1D- and 2D-N"],"journal":["Plants (Basel, Switzerland)"],"pubmed_title":["<i>Pulicaria dysenterica</i> (L.) Bernh.-Rightfully Earned Name? Identification and Biological Activity of New 3-Methoxycuminyl Esters from <i>P. dysenterica</i> Essential Oil."],"pmcid":["PMC9739903"],"funding_grant_id":["451-03-68/2022-14/200124 and 451-03-68/2022-14/200113"],"pubmed_authors":["Radulovic NS","Stojanovic NM","Boylan F","Mladenovic MZ","Randjelovic PJ","Vukicevic DR","Stojanovic-Radic ZZ"],"additional_accession":[]},"is_claimable":false,"name":"<i>Pulicaria dysenterica</i> (L.) Bernh.-Rightfully Earned Name? Identification and Biological Activity of New 3-Methoxycuminyl Esters from <i>P. dysenterica</i> Essential Oil.","description":"Motivated by the ethnopharmacological use of <i>Pulicaria dysenterica</i>, in the present study, the antimicrobial potential of the extracted essential oil was investigated against a panel of eighteen microorganism strains. Additionally, anti-acetylcholinesterase and antispasmodic (isolated rat distal colon) activities, general acute toxicity (<i>Artemia salina</i> model), and immunomodulatory properties (cytotoxicity on isolated mouse macrophages) were studied. Detailed analyses of the essential oil led to the identification of 3-methoxycuminyl 2-methylbutanoate (a new natural product) and 3-methoxycuminyl 3-methylbutanoate (a rare natural product). The obtained esters and intermediates in the synthesis of the starting alcohol (3-methoxycuminol) were subjected to a battery of 1D- and 2D-N","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T19:19:49.809Z","creation":"2024-11-19T15:15:15.49Z"},"accession":"S-EPMC9739903","cross_references":{"pubmed":["36501379"],"doi":["10.3390/plants11233340"]}}