biostudies-literatureWang HMinistry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology of the People’s Republic of China5059https://www.ebi.ac.uk/biostudies/studies/S-EPMC9740404biostudies-literatureUnknown14(23)Polyester is a kind of polymer composed of ester bond-linked polybasic acids and polyol. This type of polymer has a wide range of applications in various industries, such as automotive, furniture, coatings, packaging, and biomedical. The traditional process of synthesizing polyester mainly uses metal catalyst polymerization under high-temperature. This condition may have problems with metal residue and undesired side reactions. As an alternative, enzyme-catalyzed polymerization is evolving rapidly due to the metal-free residue, satisfactory biocompatibility, and mild reaction conditions. This article presented the reaction modes of enzyme-catalyzed ring-opening polymerization and enzyme-catalyzed polycondensation and their combinations, respectively. In addition, the article also summarizePolymersRecent Advances in the Enzymatic Synthesis of Polyester.PMC9740404SQ2020YFF0422761Li HLee CKTay GSWang HMat Nanyan NSfalseRecent Advances in the Enzymatic Synthesis of Polyester.Polyester is a kind of polymer composed of ester bond-linked polybasic acids and polyol. This type of polymer has a wide range of applications in various industries, such as automotive, furniture, coatings, packaging, and biomedical. The traditional process of synthesizing polyester mainly uses metal catalyst polymerization under high-temperature. This condition may have problems with metal residue and undesired side reactions. As an alternative, enzyme-catalyzed polymerization is evolving rapidly due to the metal-free residue, satisfactory biocompatibility, and mild reaction conditions. This article presented the reaction modes of enzyme-catalyzed ring-opening polymerization and enzyme-catalyzed polycondensation and their combinations, respectively. In addition, the article also summarize2022-01-01T00:00:00Z2022 Nov2026-04-08T11:37:42.395Z2025-04-04T23:37:02.378ZS-EPMC97404043650145410.3390/polym14235059