biostudies-literatureDe Grassi AUniversity of Bari Aldo MoroEngineering and Physical Sciences Research CouncilUniversity of Bari3725https://www.ebi.ac.uk/biostudies/studies/S-EPMC9741089biostudies-literatureUnknown11(23)The <i>cry-Ste</i> system is a genetic interaction system between heterochromatin and euchromatin in <i>Drosophila melanogaster</i>, regulated via the piRNA pathway. Deregulation of this system leads to meiotic defects and male sterility. Although the <i>cry-Ste</i> system is peculiar to <i>D. melanogaster</i>, ancestors of <i>Ste</i> and <i>Su(Ste</i>) elements are present in the three closely related species, <i>D. simulans</i>, <i>D. sechellia</i>, and <i>D. mauritiana</i>. The birth, evolution, and maintenance of this genetic system in <i>Drosophila melanogaster</i> are of interest. We investigate the presence of sequences homologous to <i>cry</i> and <i>Ste</i> elements in the simulans complex and describe their chromosomal distribution. The organization and expression of <i>cry</i>- CellsThe <i>Drosophila simulans</i> Genome Lacks the <i>crystal</i>-<i>Stellate</i> System.PMC974108900547018RicatEP/M028267/1Fondi di Ateneo, Supporto alla Ricerca 00547018Ricat (M.F.B.)De Grassi ABozzetti MPTritto PPalumbo VBerloco MFfalseThe <i>Drosophila simulans</i> Genome Lacks the <i>crystal</i>-<i>Stellate</i> System.The <i>cry-Ste</i> system is a genetic interaction system between heterochromatin and euchromatin in <i>Drosophila melanogaster</i>, regulated via the piRNA pathway. Deregulation of this system leads to meiotic defects and male sterility. Although the <i>cry-Ste</i> system is peculiar to <i>D. melanogaster</i>, ancestors of <i>Ste</i> and <i>Su(Ste</i>) elements are present in the three closely related species, <i>D. simulans</i>, <i>D. sechellia</i>, and <i>D. mauritiana</i>. The birth, evolution, and maintenance of this genetic system in <i>Drosophila melanogaster</i> are of interest. We investigate the presence of sequences homologous to <i>cry</i> and <i>Ste</i> elements in the simulans complex and describe their chromosomal distribution. The organization and expression of <i>cry</i>- 2022-01-01T00:00:00Z2022 Nov2026-06-20T03:20:36.803Z2024-11-13T23:32:25.3ZS-EPMC97410893649698510.3390/cells11233725