biostudies-literatureUnknownXu QNEI NIH HHSNational Eye InstituteAging, a universal process that affects all cells in an organism, is a major risk factor for a group of neuropathies called glaucoma, where elevated intraocular pressure is one of the known stresses affecting the tissue. Our understanding of molecular impact of aging on response to stress in retina is very limited; therefore, we developed a new mouse model to approach this question experimentally. Here we show that susceptibility to response to stress increases with age and is primed on chromatin level. We demonstrate that ocular hypertension activates a stress response that is similar to natural aging and involves activation of inflammation and senescence. We show that multiple instances of pressure elevation cause aging of young retina as measured on transcriptional and DNA methylation lAging celle13737https://www.ebi.ac.uk/biostudies/studies/S-EPMC9741506biostudies-literatureStress induced aging in mouse eye.PMC9741506EY031697EY027011R01 EY031697Cho WJabari MJu WKBrooke RTWeinreb RNRydz CXu QRocha LSkowronska-Krawczyk DLee IDonello JHorvath SFoik ANguyen Huu VALyon DCPalomino La Torre CfalseStress induced aging in mouse eye.Aging, a universal process that affects all cells in an organism, is a major risk factor for a group of neuropathies called glaucoma, where elevated intraocular pressure is one of the known stresses affecting the tissue. Our understanding of molecular impact of aging on response to stress in retina is very limited; therefore, we developed a new mouse model to approach this question experimentally. Here we show that susceptibility to response to stress increases with age and is primed on chromatin level. We demonstrate that ocular hypertension activates a stress response that is similar to natural aging and involves activation of inflammation and senescence. We show that multiple instances of pressure elevation cause aging of young retina as measured on transcriptional and DNA methylation l2022-01-01T00:00:00Z2022 Nov2025-04-04T19:11:32.589Z2025-04-04T19:11:32.589ZS-EPMC97415063639765310.1111/acel.13737