biostudies-literatureKalmbach DANHLBI NIH HHSNational Heart, Lung, and Blood Institutezsac251https://www.ebi.ac.uk/biostudies/studies/S-EPMC9742891biostudies-literatureUnknown45(12)<h4>Study objectives</h4>Insomnia is associated with elevated levels of suicidal thoughts and behaviors. Emerging evidence suggests that cognitive-behavioral therapy for insomnia (CBTI) may reduce suicidal ideation (SI). However, the role of digital therapeutics in both the alleviation and prevention of SI remains unclear, and treatment mechanisms facilitating SI reductions have not been clearly identified.<h4>Methods</h4>A total of 658 adults with Diagnostic and Statistical Manual of Mental Disorders, 5th Edition insomnia disorder enrolled in a single-site randomized controlled trial evaluating the efficacy of digital CBTI relative to attention control. Outcomes were measured at pretreatment, posttreatment, and 1-year follow-up.<h4>Results</h4>Before treatment, 126 patients endorsed SI (1SleepCognitive-behavioral therapy for insomnia prevents and alleviates suicidal ideation: insomnia remission is a suicidolytic mechanism.PMC9742891K23HL138166K23 HL138166Sagong CDrake CLSeymour GMRuprich MKCheng PAhmedani BKReffi ANKalmbach DAPeterson ELfalseCognitive-behavioral therapy for insomnia prevents and alleviates suicidal ideation: insomnia remission is a suicidolytic mechanism.<h4>Study objectives</h4>Insomnia is associated with elevated levels of suicidal thoughts and behaviors. Emerging evidence suggests that cognitive-behavioral therapy for insomnia (CBTI) may reduce suicidal ideation (SI). However, the role of digital therapeutics in both the alleviation and prevention of SI remains unclear, and treatment mechanisms facilitating SI reductions have not been clearly identified.<h4>Methods</h4>A total of 658 adults with Diagnostic and Statistical Manual of Mental Disorders, 5th Edition insomnia disorder enrolled in a single-site randomized controlled trial evaluating the efficacy of digital CBTI relative to attention control. Outcomes were measured at pretreatment, posttreatment, and 1-year follow-up.<h4>Results</h4>Before treatment, 126 patients endorsed SI (12022-01-01T00:00:00Z2022 Dec2026-07-14T19:24:53.935Z2025-04-04T11:00:47.427ZS-EPMC97428913624260710.1093/sleep/zsac251