{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Freeman EE"],"funding":["CIHR"],"pagination":["9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9742963"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["63(13)"],"pubmed_abstract":["Purpose
Studies examining the apolipoprotein E (APOE) ε4 allele and glaucoma are inconsistent, which could be due to interactions with other factors. We examined the relationship between the APOE ε4 allele and glaucoma and intraocular pressure in a large, population-based random sample and explored whether the APOE ε4 allele interacted with systemic hypertension.Methods
Data came from the Canadian Longitudinal Study on Aging, a population-based study that included 24,655 adults ages 45 to 85 years old in the European ancestry cohort. APOE genotypes were derived from single-nucleotide polymorphisms rs429358 and rs7412. Participants were asked about a prior diagnosis of glaucoma from a doctor. Corneal compensated intraocular pressure (IOP) was measured using the Reichart Ocul"],"journal":["Investigative ophthalmology & visual science"],"pubmed_title":["Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging."],"pmcid":["PMC9742963"],"funding_grant_id":["LSA 94473","PJT-180615"],"pubmed_authors":["Grant A","Li G","Buhrmann R","Bastasic J","Freeman EE","Roy-Gagnon MH","Leung G"],"additional_accession":[]},"is_claimable":false,"name":"Inverse Association of APOE ε4 and Glaucoma Modified by Systemic Hypertension: The Canadian Longitudinal Study on Aging.","description":"Purpose
Studies examining the apolipoprotein E (APOE) ε4 allele and glaucoma are inconsistent, which could be due to interactions with other factors. We examined the relationship between the APOE ε4 allele and glaucoma and intraocular pressure in a large, population-based random sample and explored whether the APOE ε4 allele interacted with systemic hypertension.Methods
Data came from the Canadian Longitudinal Study on Aging, a population-based study that included 24,655 adults ages 45 to 85 years old in the European ancestry cohort. APOE genotypes were derived from single-nucleotide polymorphisms rs429358 and rs7412. Participants were asked about a prior diagnosis of glaucoma from a doctor. Corneal compensated intraocular pressure (IOP) was measured using the Reichart Ocul","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T07:15:17.855Z","creation":"2024-11-20T04:19:04.148Z"},"accession":"S-EPMC9742963","cross_references":{"pubmed":["36479943"],"doi":["10.1167/iovs.63.13.9"]}}