{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(5)"],"submitter":["Hong D"],"pubmed_abstract":["<h4>Background</h4>There are limited data regarding comparative prognosis and medical cost between fractional flow reserve (FFR)-based and angiography-based percutaneous coronary intervention (PCI) among revascularized patients.<h4>Objectives</h4>This study evaluates prognosis and medical cost of FFR use in revascularized patients by PCI.<h4>Methods</h4>Using the National Health Insurance Service database, stable or unstable angina patients who underwent PCI from 2011 to 2017 were evaluated. Eligible patients were divided into 2 groups according to use of FFR in PCI. Primary outcome was a composite of all-cause death or spontaneous myocardial infarction (MI). Secondary outcomes included individual components of the primary outcome, unplanned revascularization, and medical costs.<h4>Results</h4>Among 134,613 eligible patients, PCI was performed based on angiography (n = 129,497) and FFR (n = 5,116). During the study period, both the annual number and proportion of use of FFR in PCI increased (all <i>P</i> for trend <0.001). The FFR group showed significantly lower risk of the primary outcome (7.0% vs 9.5%; <i>P</i> < 0.001), all-cause death (5.8% vs 7.7%; <i>P =</i> 0.001), and spontaneous MI (1.6% vs 2.2%; <i>P =</i> 0.022) than the angiography group. Although the FFR group showed higher medical cost during index admission than angiography group (median: $6,265.10 vs $5,385.60; <i>P</i> < 0.001), cumulative medical cost after index admission was significantly lower ($2,696.50 vs. $3,142.10; <i>P</i> < 0.001).<h4>Conclusions</h4>Use of FFR in PCI in stable or unstable angina patients showed significantly lower risk of all-cause death and spontaneous MI compared to angiography-based PCI. Although the FFR group had higher initial medical cost than the angiography group, cumulative medical cost after index admission was significantly lower."],"journal":["JACC. Asia"],"pagination":["590-603"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9743455"],"repository":["biostudies-literature"],"pubmed_title":["Prognosis and Medical Cost of Measuring Fractional Flow Reserve in Percutaneous Coronary Intervention."],"pmcid":["PMC9743455"],"pubmed_authors":["Kim HK","Hahn JY","Shin D","Yang JH","Choi SH","Gwon HC","Lee SH","Hong D","Song YB","Lee JM","Choi KH","Park TK"],"additional_accession":[]},"is_claimable":false,"name":"Prognosis and Medical Cost of Measuring Fractional Flow Reserve in Percutaneous Coronary Intervention.","description":"<h4>Background</h4>There are limited data regarding comparative prognosis and medical cost between fractional flow reserve (FFR)-based and angiography-based percutaneous coronary intervention (PCI) among revascularized patients.<h4>Objectives</h4>This study evaluates prognosis and medical cost of FFR use in revascularized patients by PCI.<h4>Methods</h4>Using the National Health Insurance Service database, stable or unstable angina patients who underwent PCI from 2011 to 2017 were evaluated. Eligible patients were divided into 2 groups according to use of FFR in PCI. Primary outcome was a composite of all-cause death or spontaneous myocardial infarction (MI). Secondary outcomes included individual components of the primary outcome, unplanned revascularization, and medical costs.<h4>Results</h4>Among 134,613 eligible patients, PCI was performed based on angiography (n = 129,497) and FFR (n = 5,116). During the study period, both the annual number and proportion of use of FFR in PCI increased (all <i>P</i> for trend <0.001). The FFR group showed significantly lower risk of the primary outcome (7.0% vs 9.5%; <i>P</i> < 0.001), all-cause death (5.8% vs 7.7%; <i>P =</i> 0.001), and spontaneous MI (1.6% vs 2.2%; <i>P =</i> 0.022) than the angiography group. Although the FFR group showed higher medical cost during index admission than angiography group (median: $6,265.10 vs $5,385.60; <i>P</i> < 0.001), cumulative medical cost after index admission was significantly lower ($2,696.50 vs. $3,142.10; <i>P</i> < 0.001).<h4>Conclusions</h4>Use of FFR in PCI in stable or unstable angina patients showed significantly lower risk of all-cause death and spontaneous MI compared to angiography-based PCI. Although the FFR group had higher initial medical cost than the angiography group, cumulative medical cost after index admission was significantly lower.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T12:36:59.296Z","creation":"2025-04-04T12:36:59.296Z"},"accession":"S-EPMC9743455","cross_references":{"pubmed":["36518721"],"doi":["10.1016/j.jacasi.2022.04.006"]}}