{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Miyama T"],"funding":["Ministry of Health, Labour and Welfare","Strategic International Collaborative Research Program","Japan Agency for Medical Research and Development","Environmental Restoration and Conservation Agency","Japan Society for the Promotion of Science"],"pagination":["e197"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9744460"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["150"],"pubmed_abstract":["Coronavirus disease 2019 (COVID-19) has been described as having an overdispersed offspring distribution, i.e. high variation in the number of secondary transmissions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) per single primary COVID-19 case. Accordingly, countermeasures focused on high-risk settings and contact tracing could efficiently reduce secondary transmissions. However, as variants of concern with elevated transmissibility continue to emerge, controlling COVID-19 with such focused approaches has become difficult. It is vital to quantify temporal variations in the offspring distribution dispersibility. Here, we investigated offspring distributions for periods when the ancestral variant was still dominant (summer, 2020; wave 2) and when Alpha variant (B.1.1.7) w"],"journal":["Epidemiology and infection"],"pubmed_title":["Decrease in overdispersed secondary transmission of COVID-19 over time in Japan."],"pmcid":["PMC9744460"],"funding_grant_id":["JP20fk0108140, JP20fk0108535, and JP21fk0108612","21H03198","19K24219 and 22K17410","JPMEERF20S11804","20J2135800","JPMJSC20U3 and JPMJSC2105","(20CA2024, 20HA2007, 21HB1002 and 21HA2016"],"pubmed_authors":["Miyama T","Jung SM","Nishiura H"],"additional_accession":[]},"is_claimable":false,"name":"Decrease in overdispersed secondary transmission of COVID-19 over time in Japan.","description":"Coronavirus disease 2019 (COVID-19) has been described as having an overdispersed offspring distribution, i.e. high variation in the number of secondary transmissions of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) per single primary COVID-19 case. Accordingly, countermeasures focused on high-risk settings and contact tracing could efficiently reduce secondary transmissions. However, as variants of concern with elevated transmissibility continue to emerge, controlling COVID-19 with such focused approaches has become difficult. It is vital to quantify temporal variations in the offspring distribution dispersibility. Here, we investigated offspring distributions for periods when the ancestral variant was still dominant (summer, 2020; wave 2) and when Alpha variant (B.1.1.7) w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T05:46:57.571Z","creation":"2025-04-06T11:36:46.484Z"},"accession":"S-EPMC9744460","cross_references":{"pubmed":["36377373"],"doi":["10.1017/S0950268822001789"]}}