{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lauffer M"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NIMH NIH HHS","National Institute of Mental Health","Roy J. Carver Charitable Trust"],"pagination":["e12791"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9744532"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(2)"],"pubmed_abstract":["L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca<sub>V</sub> 1.3. Mice lacking Ca<sub>V</sub> 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca<sub>V</sub> 1.3 function in the hippocampus and amygdala. Genetic variation in Ca<sub>V</sub> 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning and social function. Here, we explored whether Ca<sub>V</sub> 1.3 plays a role in these behaviors. We found that Ca<sub>V</sub> 1.3 knockout mice have deficits in r"],"journal":["Genes, brain, and behavior"],"pubmed_title":["Deletion of the voltage-gated calcium channel, Ca<sub>V</sub> 1.3, causes deficits in motor performance and associative learning."],"pmcid":["PMC9744532"],"funding_grant_id":["R01MH118240","KL2TR002536","R01 MH118240","K01MH106824","KL2 TR002536"],"pubmed_authors":["Wen H","Myers B","Parker K","Williams A","Lauffer M","Plumb A"],"additional_accession":[]},"is_claimable":false,"name":"Deletion of the voltage-gated calcium channel, Ca<sub>V</sub> 1.3, causes deficits in motor performance and associative learning.","description":"L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca<sub>V</sub> 1.3. Mice lacking Ca<sub>V</sub> 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca<sub>V</sub> 1.3 function in the hippocampus and amygdala. Genetic variation in Ca<sub>V</sub> 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning and social function. Here, we explored whether Ca<sub>V</sub> 1.3 plays a role in these behaviors. We found that Ca<sub>V</sub> 1.3 knockout mice have deficits in r","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-18T23:26:47.331Z","creation":"2025-04-07T11:00:30.177Z"},"accession":"S-EPMC9744532","cross_references":{"pubmed":["35044095"],"doi":["10.1111/gbb.12791"]}}