biostudies-literatureLauffer MNational Center for Advancing Translational SciencesNCATS NIH HHSNIMH NIH HHSNational Institute of Mental HealthRoy J. Carver Charitable Truste12791https://www.ebi.ac.uk/biostudies/studies/S-EPMC9744532biostudies-literatureUnknown21(2)L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca_V 1.3. Mice lacking Ca_V 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca_V 1.3 function in the hippocampus and amygdala. Genetic variation in Ca_V 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning and social function. Here, we explored whether Ca_V 1.3 plays a role in these behaviors. We found that Ca_V 1.3 knockout mice have deficits in rGenes, brain, and behaviorDeletion of the voltage-gated calcium channel, Ca_V 1.3, causes deficits in motor performance and associative learning.PMC9744532R01MH118240KL2TR002536R01 MH118240K01MH106824KL2 TR002536Wen HMyers BParker KWilliams ALauffer MPlumb AfalseDeletion of the voltage-gated calcium channel, Ca_V 1.3, causes deficits in motor performance and associative learning.L-type voltage-gated calcium channels are important regulators of neuronal activity and are widely expressed throughout the brain. One of the major L-type voltage-gated calcium channel isoforms in the brain is Ca_V 1.3. Mice lacking Ca_V 1.3 are reported to have impairments in fear conditioning and depressive-like behaviors, which have been linked to Ca_V 1.3 function in the hippocampus and amygdala. Genetic variation in Ca_V 1.3 has been linked to a variety of psychiatric disorders, including autism and schizophrenia, which are associated with altered motor learning, associative learning and social function. Here, we explored whether Ca_V 1.3 plays a role in these behaviors. We found that Ca_V 1.3 knockout mice have deficits in r2022-01-01T00:00:00Z2022 Feb2025-04-18T23:26:47.331Z2025-04-07T11:00:30.177ZS-EPMC97445323504409510.1111/gbb.12791