{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Ma C"],"pubmed_abstract":["We reported a general transition metal-free transformation to access C3-carbamoylated 2<i>H</i>-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs<sub>2</sub>CO<sub>3</sub> as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product."],"journal":["Frontiers in chemistry"],"pagination":["1087834"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9745185"],"repository":["biostudies-literature"],"pubmed_title":["Visible light-promoted transition metal-free direct C3-carbamoylation of 2<i>H</i>-Indazoles."],"pmcid":["PMC9745185"],"pubmed_authors":["Jiang Y","Ma C","Zhang D","Shang L","He X","Zhao H","Lv Q"],"additional_accession":[]},"is_claimable":false,"name":"Visible light-promoted transition metal-free direct C3-carbamoylation of 2<i>H</i>-Indazoles.","description":"We reported a general transition metal-free transformation to access C3-carbamoylated 2<i>H</i>-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs<sub>2</sub>CO<sub>3</sub> as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T19:49:24.387Z","creation":"2025-04-04T19:49:24.387Z"},"accession":"S-EPMC9745185","cross_references":{"pubmed":["36523748"],"doi":["10.3389/fchem.2022.1087834"]}}