biostudies-literatureUnknown10Ma CWe reported a general transition metal-free transformation to access C3-carbamoylated 2<i>H</i>-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs₂CO₃ as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product.Frontiers in chemistry1087834https://www.ebi.ac.uk/biostudies/studies/S-EPMC9745185biostudies-literatureVisible light-promoted transition metal-free direct C3-carbamoylation of 2<i>H</i>-Indazoles.PMC9745185Jiang YMa CZhang DShang LHe XZhao HLv QfalseVisible light-promoted transition metal-free direct C3-carbamoylation of 2<i>H</i>-Indazoles.We reported a general transition metal-free transformation to access C3-carbamoylated 2<i>H</i>-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs₂CO₃ as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product.2022-01-01T00:00:00Z20222025-04-04T19:49:24.387Z2025-04-04T19:49:24.387ZS-EPMC97451853652374810.3389/fchem.2022.1087834