{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chuprom J"],"funding":["Botanical Garden of Walailak University"],"pagination":["e14468"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9745913"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["<i>Garcinia mangostana</i> L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin. In this study, we examined the pharmacological activities of the selected semi-synthetic mangostin derivative, namely, amoebicidal activity, encystation inhibition, excystation activity, and removal capacity of adhesive <i>Acanthamoeba</i> from the surface of contact lens (CL). Among the three derivatives, C1 exhibited promising anti-<i>Acanthamoeba</i> activity against <i>Acanthamoeba triangularis</i> WU19001 trophozoites and cysts. SEM images displayed morphological changes in <i>Acanthamoeba</i> trophozoites, including the loss of acanthopodia, pore formation in the cell membrane, and "],"journal":["PeerJ"],"pubmed_title":["Anti-<i>Acanthamoeba</i> activity of a semi-synthetic mangostin derivative and its ability in removal of <i>Acanthamoeba triangularis</i> WU19001 on contact lens."],"pmcid":["PMC9745913"],"funding_grant_id":["WUBG 031-2565, UIDB/50011/2020, UIDP/50011/2020 &amp; LA/P/0006/2020, FCT/MEC (PIDDAC)"],"pubmed_authors":["Pereira ML","Wilairatana P","Wiart C","Surinkaew S","Mahabusarakam W","Jitrangsri K","Singh LR","Rahmatullah M","Chuprom J","Nissapatorn V","Sangkanu S","Boonhok R","Paul AK","Oliveira SMR","Dumkliang E","Mitsuwan W"],"additional_accession":[]},"is_claimable":false,"name":"Anti-<i>Acanthamoeba</i> activity of a semi-synthetic mangostin derivative and its ability in removal of <i>Acanthamoeba triangularis</i> WU19001 on contact lens.","description":"<i>Garcinia mangostana</i> L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin. In this study, we examined the pharmacological activities of the selected semi-synthetic mangostin derivative, namely, amoebicidal activity, encystation inhibition, excystation activity, and removal capacity of adhesive <i>Acanthamoeba</i> from the surface of contact lens (CL). Among the three derivatives, C1 exhibited promising anti-<i>Acanthamoeba</i> activity against <i>Acanthamoeba triangularis</i> WU19001 trophozoites and cysts. SEM images displayed morphological changes in <i>Acanthamoeba</i> trophozoites, including the loss of acanthopodia, pore formation in the cell membrane, and ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-20T03:15:49.791Z","creation":"2025-02-18T23:49:56.759Z"},"accession":"S-EPMC9745913","cross_references":{"pubmed":["36523474"],"doi":["10.7717/peerj.14468"]}}