biostudies-literatureChuprom JBotanical Garden of Walailak Universitye14468https://www.ebi.ac.uk/biostudies/studies/S-EPMC9745913biostudies-literatureUnknown10<i>Garcinia mangostana</i> L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin. In this study, we examined the pharmacological activities of the selected semi-synthetic mangostin derivative, namely, amoebicidal activity, encystation inhibition, excystation activity, and removal capacity of adhesive <i>Acanthamoeba</i> from the surface of contact lens (CL). Among the three derivatives, C1 exhibited promising anti-<i>Acanthamoeba</i> activity against <i>Acanthamoeba triangularis</i> WU19001 trophozoites and cysts. SEM images displayed morphological changes in <i>Acanthamoeba</i> trophozoites, including the loss of acanthopodia, pore formation in the cell membrane, and PeerJAnti-<i>Acanthamoeba</i> activity of a semi-synthetic mangostin derivative and its ability in removal of <i>Acanthamoeba triangularis</i> WU19001 on contact lens.PMC9745913WUBG 031-2565, UIDB/50011/2020, UIDP/50011/2020 &amp; LA/P/0006/2020, FCT/MEC (PIDDAC)Pereira MLWilairatana PWiart CSurinkaew SMahabusarakam WJitrangsri KSingh LRRahmatullah MChuprom JNissapatorn VSangkanu SBoonhok RPaul AKOliveira SMRDumkliang EMitsuwan WfalseAnti-<i>Acanthamoeba</i> activity of a semi-synthetic mangostin derivative and its ability in removal of <i>Acanthamoeba triangularis</i> WU19001 on contact lens.<i>Garcinia mangostana</i> L., also known as the mangosteen tree, is a native medicinal plant in Southeast Asia having a wide variety of pharmacologically active compounds, including xanthonoid mangostin. In this study, we examined the pharmacological activities of the selected semi-synthetic mangostin derivative, namely, amoebicidal activity, encystation inhibition, excystation activity, and removal capacity of adhesive <i>Acanthamoeba</i> from the surface of contact lens (CL). Among the three derivatives, C1 exhibited promising anti-<i>Acanthamoeba</i> activity against <i>Acanthamoeba triangularis</i> WU19001 trophozoites and cysts. SEM images displayed morphological changes in <i>Acanthamoeba</i> trophozoites, including the loss of acanthopodia, pore formation in the cell membrane, and 2022-01-01T00:00:00Z20222026-06-20T03:15:49.791Z2025-02-18T23:49:56.759ZS-EPMC97459133652347410.7717/peerj.14468