{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo X"],"funding":["Translational Medicine Cross Research Fund of Shanghai Jiao Tong University","Clinical Research Plan of Shanghai Hospital Development Center","Shanghai Collaborative Innovation Center for Translational Medicine Fund","National Natural Science Foundation of China"],"pagination":["531"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9749152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Acute myocardial infarction (AMI) is usually caused by coronary thrombosis. However, the short half-life, lack of targetability and inevitable ischemia/reperfusion injury secondary to revascularization, which characterizes tissue plasminogen activator (tPA) limit its thrombolytic efficacy for AMI. To address the targeted and site-specific delivery of tPA, the current study reports the construction of a thrombus-targeting and responsive biomimetic nanoparticle (PTPN) for spatiotemporal treatment of AMI. PTPN was constituted by the thrombus microenvironment- responsive phenylboronic acid (PBA) nanocarrier, antioxidant molecular protocatechualdehyde (PC) and tPA with thrombolytic effect, which were enclosed by the platelet membrane. The thrombus-targeting capability of the platelet membrane e"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Thrombus-specific/responsive biomimetic nanomedicine for spatiotemporal thrombolysis and alleviation of myocardial ischemia/reperfusion injury."],"pmcid":["PMC9749152"],"funding_grant_id":["NO.TM202013","No.SHDC2020CR3084B","No.YG2021ZD27, YG2022QN101 and YG2022ZD025","Nos.81901419, 82072199 and 82172168"],"pubmed_authors":["Zang J","Guo X","Hong T","Shao R","Hou X","He B","Wang K","Liu W","Su F"],"additional_accession":[]},"is_claimable":false,"name":"Thrombus-specific/responsive biomimetic nanomedicine for spatiotemporal thrombolysis and alleviation of myocardial ischemia/reperfusion injury.","description":"Acute myocardial infarction (AMI) is usually caused by coronary thrombosis. However, the short half-life, lack of targetability and inevitable ischemia/reperfusion injury secondary to revascularization, which characterizes tissue plasminogen activator (tPA) limit its thrombolytic efficacy for AMI. To address the targeted and site-specific delivery of tPA, the current study reports the construction of a thrombus-targeting and responsive biomimetic nanoparticle (PTPN) for spatiotemporal treatment of AMI. PTPN was constituted by the thrombus microenvironment- responsive phenylboronic acid (PBA) nanocarrier, antioxidant molecular protocatechualdehyde (PC) and tPA with thrombolytic effect, which were enclosed by the platelet membrane. The thrombus-targeting capability of the platelet membrane e","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T15:42:27.004Z","creation":"2025-04-05T15:42:27.004Z"},"accession":"S-EPMC9749152","cross_references":{"pubmed":["36514154"],"doi":["10.1186/s12951-022-01686-1"]}}