biostudies-literatureUnknown41(1)Mendogni P<h4>Background</h4>Thymic malignancies are a heterogeneous group of rare cancers for which systemic chemotherapy is the standard treatment in the setting of advanced, recurrent or refractory diseases. Both environmental and genetic risk factors have not been fully clarified and few target-specific drugs have been developed for thymic epithelial tumors. A major challenge in studying thymic epithelial tumors is the lack of preclinical models for translational studies.<h4>Main body</h4>Starting from bioptic material of two consecutive recurrences of the same patient, we generated two patient-derived xenografts. The patient-derived xenografts models were characterized for histology by immunohistochemistry and mutations using next-generation sequencing. When compared to the original tumors reseJournal of experimental & clinical cancer research : CR343https://www.ebi.ac.uk/biostudies/studies/S-EPMC9749328biostudies-literatureIsolation and characterization of two newly established thymoma PDXs from two relapses of the same patient: a new tool to investigate thymic malignancies.PMC9749328Mendogni PCabri EFratelli MMarabese MDel Gobbo AAffatato RChiappa MRosso LPetrini IBroggini MNdembe GTosi DPardini EfalseIsolation and characterization of two newly established thymoma PDXs from two relapses of the same patient: a new tool to investigate thymic malignancies.<h4>Background</h4>Thymic malignancies are a heterogeneous group of rare cancers for which systemic chemotherapy is the standard treatment in the setting of advanced, recurrent or refractory diseases. Both environmental and genetic risk factors have not been fully clarified and few target-specific drugs have been developed for thymic epithelial tumors. A major challenge in studying thymic epithelial tumors is the lack of preclinical models for translational studies.<h4>Main body</h4>Starting from bioptic material of two consecutive recurrences of the same patient, we generated two patient-derived xenografts. The patient-derived xenografts models were characterized for histology by immunohistochemistry and mutations using next-generation sequencing. When compared to the original tumors rese2022-01-01T00:00:00Z2022 Dec2025-04-18T11:44:06.715Z2024-10-15T01:30:03.123ZS-EPMC97493283651782910.1186/s13046-022-02554-4