{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ong YY"],"funding":["Singapore Ministry of Health’s National Medical Research Council","British Heart Foundation","Singapore National Research Foundation","Medical Research Council","National Institute for Health Research (NIHR)","NIHR Southampton Biomedical Research Centre","Translational and Clinical Research"],"pagination":["1835-1846"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9749728"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(6)"],"pubmed_abstract":["Early epidemiological studies have associated low birthweight with increased cardiovascular risk. We aimed to examine whether the fat and fat-free components of birthweight have differing relationships with childhood cardiovascular risk markers. In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, air displacement plethysmography was conducted within 24 h after delivery in 290 naturally conceived singletons. We investigated associations of newborn cohort-specific standardized z-score of fat mass, fat-free mass, body fat percentage and birthweight on child (at 6 years of age) carotid intima-media thickness, pulse wave velocity, blood pressure, prehypertension/hypertension (>110/70 mmHg) and standardized systolic and diastolic blood pressure (SBP and DBP) trajectories (at 3-6 years of age), taking account of maternal education, height, tobacco exposure, parity, ethnicity, child's sex, gestational age, age at follow-up, and other maternal factors. Clear inverse associations were seen for blood pressure with z-score of fat mass [SBP, β (95% CI): -1.31 mmHg (-2.57, -0.06); DBP: -0.79 mmHg (-1.74, 0.15)] and body fat percentage [SBP: -1.46 mmHg (-2.73, -0.19); DBP: -0.80 mmHg (-1.75, 0.16)], but not with fat-free mass [SBP: 0.27 mmHg (-1.29, 1.83)]; DBP: -0.14 mmHg (-1.30, 1.03)]. Being in the lowest tertile of fat mass or body fat percentage was associated with higher blood pressure trajectories and prehypertension/hypertension risk [OR (95% CI), fat mass: 4.23 (1.41, 12.68); body fat percentage: 3.22 (1.09, 9.53)] without concomitantly higher overweight/obesity risk. At birth, low adiposity was associated with increased childhood blood pressure. Low newborn adiposity might serve as a marker of poor fetal growth or suboptimal intrauterine conditions associated with hypertension risk later in life."],"journal":["International journal of epidemiology"],"pubmed_title":["Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study."],"pmcid":["PMC9749728"],"funding_grant_id":["NMRC/TCR/004-NUS/2008","MC_UU_12011/4","NMRC/TCR/012-NUHS/2014","RG/15/17/31749","NIHR200286","NF-SI-0515-10042","RG/15/17/3174","MC_UU_00006/2","IS-BRC-1215-20004"],"pubmed_authors":["Lee YS","Ling LH","Chen LW","Chong MF","De Lucia Rolfe E","Chong YS","Shek L","Godfrey KM","Choo J","Michael N","Eriksson JG","Aris IM","Wlodek ME","Ong YY","Fortier MV","Ong KK","Chan SY","Tint MT","Yuan WL","Gluckman PD","Tan KH","Yap F"],"additional_accession":[]},"is_claimable":false,"name":"Newborn body composition and child cardiovascular risk markers: a prospective multi-ethnic Asian cohort study.","description":"Early epidemiological studies have associated low birthweight with increased cardiovascular risk. We aimed to examine whether the fat and fat-free components of birthweight have differing relationships with childhood cardiovascular risk markers. In the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort, air displacement plethysmography was conducted within 24 h after delivery in 290 naturally conceived singletons. We investigated associations of newborn cohort-specific standardized z-score of fat mass, fat-free mass, body fat percentage and birthweight on child (at 6 years of age) carotid intima-media thickness, pulse wave velocity, blood pressure, prehypertension/hypertension (>110/70 mmHg) and standardized systolic and diastolic blood pressure (SBP and DBP) trajectories (at 3-6 years of age), taking account of maternal education, height, tobacco exposure, parity, ethnicity, child's sex, gestational age, age at follow-up, and other maternal factors. Clear inverse associations were seen for blood pressure with z-score of fat mass [SBP, β (95% CI): -1.31 mmHg (-2.57, -0.06); DBP: -0.79 mmHg (-1.74, 0.15)] and body fat percentage [SBP: -1.46 mmHg (-2.73, -0.19); DBP: -0.80 mmHg (-1.75, 0.16)], but not with fat-free mass [SBP: 0.27 mmHg (-1.29, 1.83)]; DBP: -0.14 mmHg (-1.30, 1.03)]. Being in the lowest tertile of fat mass or body fat percentage was associated with higher blood pressure trajectories and prehypertension/hypertension risk [OR (95% CI), fat mass: 4.23 (1.41, 12.68); body fat percentage: 3.22 (1.09, 9.53)] without concomitantly higher overweight/obesity risk. At birth, low adiposity was associated with increased childhood blood pressure. Low newborn adiposity might serve as a marker of poor fetal growth or suboptimal intrauterine conditions associated with hypertension risk later in life.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-25T20:30:24.121Z","creation":"2025-04-06T08:22:29.937Z"},"accession":"S-EPMC9749728","cross_references":{"pubmed":["35906917"],"doi":["10.1093/ije/dyac154"]}}