{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jones BO"],"funding":["Texas A&M University","NIDA NIH HHS","National Institutes of Health"],"pagination":["447-457"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9749853"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(12)"],"pubmed_abstract":["Habits are theorized to play a key role in compulsive cocaine seeking, yet there is limited methodology for assessing habitual responding for intravenous (IV) cocaine. We developed a novel outcome devaluation procedure to discriminate goal-directed from habitual responding in cocaine-seeking rats. This procedure elicits devaluation temporarily and requires no additional training, allowing repeated testing at different time points. After training male rats to self-administer IV cocaine, we devalued the drug outcome via experimenter-administered IV cocaine (a \"satiety\" procedure) prior to a 10-min extinction test. Many rats were sensitive to outcome devaluation, a hallmark of goal-directed responding. These animals reduced responding when given a dose of experimenter-administered cocaine tha"],"journal":["Learning & memory (Cold Spring Harbor, N.Y.)"],"pubmed_title":["Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure."],"pmcid":["PMC9749853"],"funding_grant_id":["R01 DA046457","R21 DA037744"],"pubmed_authors":["Kim TH","Spencer HF","Jones BO","Cruz AM","Smith RJ"],"additional_accession":[]},"is_claimable":false,"name":"Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure.","description":"Habits are theorized to play a key role in compulsive cocaine seeking, yet there is limited methodology for assessing habitual responding for intravenous (IV) cocaine. We developed a novel outcome devaluation procedure to discriminate goal-directed from habitual responding in cocaine-seeking rats. This procedure elicits devaluation temporarily and requires no additional training, allowing repeated testing at different time points. After training male rats to self-administer IV cocaine, we devalued the drug outcome via experimenter-administered IV cocaine (a \"satiety\" procedure) prior to a 10-min extinction test. Many rats were sensitive to outcome devaluation, a hallmark of goal-directed responding. These animals reduced responding when given a dose of experimenter-administered cocaine tha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-21T23:09:17.058Z","creation":"2025-04-05T19:03:12.998Z"},"accession":"S-EPMC9749853","cross_references":{"pubmed":["36621907"],"doi":["10.1101/lm.053621.122"]}}