biostudies-literatureJones BOTexas A&M UniversityNIDA NIH HHSNational Institutes of Health447-457https://www.ebi.ac.uk/biostudies/studies/S-EPMC9749853biostudies-literatureUnknown29(12)Habits are theorized to play a key role in compulsive cocaine seeking, yet there is limited methodology for assessing habitual responding for intravenous (IV) cocaine. We developed a novel outcome devaluation procedure to discriminate goal-directed from habitual responding in cocaine-seeking rats. This procedure elicits devaluation temporarily and requires no additional training, allowing repeated testing at different time points. After training male rats to self-administer IV cocaine, we devalued the drug outcome via experimenter-administered IV cocaine (a "satiety" procedure) prior to a 10-min extinction test. Many rats were sensitive to outcome devaluation, a hallmark of goal-directed responding. These animals reduced responding when given a dose of experimenter-administered cocaine thaLearning & memory (Cold Spring Harbor, N.Y.)Discriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure.PMC9749853R01 DA046457R21 DA037744Kim THSpencer HFJones BOCruz AMSmith RJfalseDiscriminating goal-directed and habitual cocaine seeking in rats using a novel outcome devaluation procedure.Habits are theorized to play a key role in compulsive cocaine seeking, yet there is limited methodology for assessing habitual responding for intravenous (IV) cocaine. We developed a novel outcome devaluation procedure to discriminate goal-directed from habitual responding in cocaine-seeking rats. This procedure elicits devaluation temporarily and requires no additional training, allowing repeated testing at different time points. After training male rats to self-administer IV cocaine, we devalued the drug outcome via experimenter-administered IV cocaine (a "satiety" procedure) prior to a 10-min extinction test. Many rats were sensitive to outcome devaluation, a hallmark of goal-directed responding. These animals reduced responding when given a dose of experimenter-administered cocaine tha2022-01-01T00:00:00Z2022 Dec2025-04-21T23:09:17.058Z2025-04-05T19:03:12.998ZS-EPMC97498533662190710.1101/lm.053621.122