{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(12)"],"submitter":["Ballantine RD"],"pubmed_abstract":["The brevicidine and laterocidine family of lipopeptide antibiotics exhibit strong activity against multidrug-resistant Gram-negative bacteria, while showing low propensity to induce resistance. Both peptides feature a branched lipid tail on the N-terminal residue, which for brevicidine is chiral. Here, we report the synthesis and biological evaluation of a library of brevicidine and laterocidine analogues wherein the N-terminal lipid is replaced with linear achiral fatty acids. Optimal lipid chain lengths were determined and new analogues with strong activity against colistin-resistant E. coli produced."],"journal":["RSC medicinal chemistry"],"pagination":["1640-1643"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9749936"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine."],"pmcid":["PMC9749936"],"pubmed_authors":["Ballantine RD","Hoekstra M","Bann SJ","Martin NI","Cochrane SA","Al Ayed K"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and structure-activity relationship studies of N-terminal analogues of the lipopeptide antibiotics brevicidine and laterocidine.","description":"The brevicidine and laterocidine family of lipopeptide antibiotics exhibit strong activity against multidrug-resistant Gram-negative bacteria, while showing low propensity to induce resistance. Both peptides feature a branched lipid tail on the N-terminal residue, which for brevicidine is chiral. Here, we report the synthesis and biological evaluation of a library of brevicidine and laterocidine analogues wherein the N-terminal lipid is replaced with linear achiral fatty acids. Optimal lipid chain lengths were determined and new analogues with strong activity against colistin-resistant E. coli produced.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T16:30:32.045Z","creation":"2025-04-07T03:44:02.835Z"},"accession":"S-EPMC9749936","cross_references":{"pubmed":["36545437"],"doi":["10.1039/d2md00281g"]}}