{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alagundagi DB"],"funding":["Economic and Social Research Council","Austrian Science Fund FWF","Children with Cancer UK","Open University - Funder","Versus Arthritis","Medical Research Council","Science and Technology Facilities Council","National Institute for Health Research (NIHR)","NordForsk","Natural Environment Research Council","Biotechnology and Biological Sciences Research Council","Engineering and Physical Sciences Research Council"],"pagination":["7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9751250"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["The comprehensive bioinformatics analysis of breast cancer exosomes revealed that HSP90AA1, CCT2, and ENO1 were novel hub genes in the giant protein-protein interaction network of 110 exosomal proteins. Exosomes and their cargo such as discrete proteins, nucleic acids, and lipids are having potential role in the pathophysiology of breast cancer (BC). This study showed that the identified hub genes were particularly abundant in GO and KEGG pathways relevant to the positive regulation of telomerase. In addition, these hub genes were found to be considerably overexpressed in breast adenocarcinoma patients compared to healthy controls, and further, this overexpression is linked to the poor prognosis in BC patients. Furthermore, the ROC analysis revealed that CCT2 gene has strong diagnostic and"],"journal":["3 Biotech"],"pubmed_title":["Exploring breast cancer exosomes for novel biomarkers of potential diagnostic and prognostic importance."],"pmcid":["PMC9751250"],"funding_grant_id":["EP/P001009/1","ES/L011719/1","EP/M007065/1","EP/G061130/1","1647095","TRP 220","EP/P025145/1","G1002252","Z 211","EP/I033335/2","EP/M013774/1","NE/I027193/1","ST/K001051/1","NF-SI-0509-10211","I 1536","EP/K028960/1","ES/N009614/1","BBS/E/C/000I0420","977884","EP/T028572/1","21356","292798","14-176","1094977","P 22416","EP/N007638/1","ES/K005170/1","1791132","ES/K00820X/1","EP/R007268/1","P 27972","86036","not_applicable","ES/F028180/1"],"pubmed_authors":["Gollapalli P","Ghate SD","Rajendra VKJ","D'Souza C","Shetty P","Alagundagi DB","Patil P","Shetty VV"],"additional_accession":[]},"is_claimable":false,"name":"Exploring breast cancer exosomes for novel biomarkers of potential diagnostic and prognostic importance.","description":"The comprehensive bioinformatics analysis of breast cancer exosomes revealed that HSP90AA1, CCT2, and ENO1 were novel hub genes in the giant protein-protein interaction network of 110 exosomal proteins. Exosomes and their cargo such as discrete proteins, nucleic acids, and lipids are having potential role in the pathophysiology of breast cancer (BC). This study showed that the identified hub genes were particularly abundant in GO and KEGG pathways relevant to the positive regulation of telomerase. In addition, these hub genes were found to be considerably overexpressed in breast adenocarcinoma patients compared to healthy controls, and further, this overexpression is linked to the poor prognosis in BC patients. Furthermore, the ROC analysis revealed that CCT2 gene has strong diagnostic and","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-21T15:11:03.668Z","creation":"2025-04-21T15:11:03.668Z"},"accession":"S-EPMC9751250","cross_references":{"pubmed":["36532861"],"doi":["10.1007/s13205-022-03422-w"]}}