biostudies-literatureVan Le TNBLRD VANHLBI NIH HHSNational Institutes of HealthFlorida Department of HealthNIGMS NIH HHSUS Department of Veterans Affairs170-180https://www.ebi.ac.uk/biostudies/studies/S-EPMC9752708biostudies-literatureUnknown637Sirtuin1 (SIRT1) is involved in regulating substrate metabolism in the cardiovascular system. Metabolic homeostasis plays a critical role in hypertrophic heart failure. We hypothesize that cardiac SIRT1 can modulate substrate metabolism during pressure overload-induced heart failure. The inducible cardiomyocyte Sirt1 knockout (icSirt1^-/-) and its wild type littermates (Sirt1^f/f) C57BL/6J mice were subjected to transverse aortic constriction (TAC) surgery to induce pressure overload. The pressure overload induces upregulation of cardiac SIRT1 in Sirt1^f/f but not icSirt1^-/- mice. The cardiac contractile dysfunctions caused by TAC-induced pressure overload occurred in Sirt1^f/f but not in icSirt1^-/- mice. Intriguingly, Sirt1<supBiochemical and biophysical research communicationsSirtuin 1 aggravates hypertrophic heart failure caused by pressure overload via shifting energy metabolism.PMC9752708R01 HL158515R01 GM124108I01 BX005625Van Le TNLi JZoungrana LIFatmi MKWang HRen DKrause-Hauch MfalseSirtuin 1 aggravates hypertrophic heart failure caused by pressure overload via shifting energy metabolism.Sirtuin1 (SIRT1) is involved in regulating substrate metabolism in the cardiovascular system. Metabolic homeostasis plays a critical role in hypertrophic heart failure. We hypothesize that cardiac SIRT1 can modulate substrate metabolism during pressure overload-induced heart failure. The inducible cardiomyocyte Sirt1 knockout (icSirt1^-/-) and its wild type littermates (Sirt1^f/f) C57BL/6J mice were subjected to transverse aortic constriction (TAC) surgery to induce pressure overload. The pressure overload induces upregulation of cardiac SIRT1 in Sirt1^f/f but not icSirt1^-/- mice. The cardiac contractile dysfunctions caused by TAC-induced pressure overload occurred in Sirt1^f/f but not in icSirt1^-/- mice. Intriguingly, Sirt1<sup2022-01-01T00:00:00Z2022 Dec2025-04-26T07:48:33.216Z2025-04-06T12:29:50.343ZS-EPMC97527083640348010.1016/j.bbrc.2022.11.014