biostudies-literatureHays RDNCCIH NIH HHSNational Center for Complementary and Integrative Health699-706https://www.ebi.ac.uk/biostudies/studies/S-EPMC9752772biostudies-literatureUnknown44(9)<h4>Objective</h4>The purpose of this study was to estimate the significance of individual change using 5 statistical indicators in 2 samples of patients treated for low back pain.<h4>Methods</h4>This secondary analysis used observational and clinical trial data from 2 samples of patients with low back pain to compare 5 ways of estimating significant individual change on the Impact Stratification Score (ISS) administered at the following 2 time points: 3 months apart in an observational study of 1680 patients undergoing chiropractic care, and 6 weeks apart in a randomized trial of 750 active-duty military personnel with low back pain. The following 5 methods were compared: (1) standard deviation index; (2) standard error of measurement (SEM); (3) standard error of estimate (SEE); (4) standJournal of manipulative and physiological therapeuticsAssessing the Significance of Individual Change in 2 Samples of Patients in Treatment for Low Back Pain Using 5 Different Statistical Indicators.PMC97527721R01AT010402-01A1R01 AT010402Slaughter MEHays RDSpritzer KLHerman PMfalseAssessing the Significance of Individual Change in 2 Samples of Patients in Treatment for Low Back Pain Using 5 Different Statistical Indicators.<h4>Objective</h4>The purpose of this study was to estimate the significance of individual change using 5 statistical indicators in 2 samples of patients treated for low back pain.<h4>Methods</h4>This secondary analysis used observational and clinical trial data from 2 samples of patients with low back pain to compare 5 ways of estimating significant individual change on the Impact Stratification Score (ISS) administered at the following 2 time points: 3 months apart in an observational study of 1680 patients undergoing chiropractic care, and 6 weeks apart in a randomized trial of 750 active-duty military personnel with low back pain. The following 5 methods were compared: (1) standard deviation index; (2) standard error of measurement (SEM); (3) standard error of estimate (SEE); (4) stand2021-01-01T00:00:00Z2021 Nov-Dec2025-04-19T10:18:01.21Z2024-11-15T11:35:27.449ZS-EPMC97527723575387810.1016/j.jmpt.2022.03.002