biostudies-literatureUnknown28(45)Zhang XQ<h4>Background</h4>The optimal method to remove sessile colorectal lesions sized 10-20 mm remains uncertain. Piecemeal and incomplete resection are major limitations in current practice, such as endoscopic mucosal resection (EMR) and cold or hot snare polypectomy. Recently, EMR with circumferential precutting (EMR-P) has emerged as an effective technique, but the quality of current evidence in comparative studies of conventional EMR (CEMR) and EMR-P is limited.<h4>Aim</h4>To investigate whether EMR-P is superior to CEMR in removing sessile colorectal polyps.<h4>Methods</h4>This multicenter randomized controlled trial involved seven medical institutions in China. Patients with colorectal polyps sized 10-20 mm were enrolled and randomly assigned to undergo EMR-P or CEMR. EMR-P was performed World journal of gastroenterology6397-6409https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753056biostudies-literatureEndoscopic mucosal resection-precutting <i>vs</i> conventional endoscopic mucosal resection for sessile colorectal polyps sized 10-20 mm.PMC9753056Xu LSang JZYu CHMao XLZhang XQLi BZhu WLYang XYfalseEndoscopic mucosal resection-precutting <i>vs</i> conventional endoscopic mucosal resection for sessile colorectal polyps sized 10-20 mm.<h4>Background</h4>The optimal method to remove sessile colorectal lesions sized 10-20 mm remains uncertain. Piecemeal and incomplete resection are major limitations in current practice, such as endoscopic mucosal resection (EMR) and cold or hot snare polypectomy. Recently, EMR with circumferential precutting (EMR-P) has emerged as an effective technique, but the quality of current evidence in comparative studies of conventional EMR (CEMR) and EMR-P is limited.<h4>Aim</h4>To investigate whether EMR-P is superior to CEMR in removing sessile colorectal polyps.<h4>Methods</h4>This multicenter randomized controlled trial involved seven medical institutions in China. Patients with colorectal polyps sized 10-20 mm were enrolled and randomly assigned to undergo EMR-P or CEMR. EMR-P was performed 2022-01-01T00:00:00Z2022 Dec2025-04-19T22:44:55.591Z2025-04-19T22:44:55.591ZS-EPMC97530563653311010.3748/wjg.v28.i45.6397