{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zucker F"],"funding":["Deutsche Forschungsgemeinschaft","Office of Science of the U.S. Department of Energy"],"pagination":["veac070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753089"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(2)"],"pubmed_abstract":["The <i>Microviridae</i> family represents one of the major clades of single-stranded DNA (ssDNA) phages. Their cultivated members are lytic and infect Proteobacteria, Bacteroidetes, and Chlamydiae. Prophages have been predicted in the genomes from Bacteroidales, Hyphomicrobiales, and Enterobacteriaceae and cluster within the 'Alpavirinae', 'Amoyvirinae', and <i>Gokushovirinae</i>. We have isolated 'Ascunsovirus oldenburgi' ICBM5, a novel phage distantly related to known <i>Microviridae</i>. It infects <i>Sulfitobacter dubius</i> SH24-1b and uses both a lytic and a carrier-state life strategy. Using ICBM5 proteins as a query, we uncovered in publicly available resources sixty-five new <i>Microviridae</i> prophages and episomes in bacterial genomes and retrieved forty-seven environmental vir"],"journal":["Virus evolution"],"pubmed_title":["New <i>Microviridae</i> isolated from <i>Sulfitobacter</i> reveals two cosmopolitan subfamilies of single-stranded DNA phages infecting marine and terrestrial Alphaproteobacteria."],"pmcid":["PMC9753089"],"funding_grant_id":["DE-AC02-05CH11231","TRR51"],"pubmed_authors":["Zucker F","Bischoff V","Roux S","Enault F","Moraru C","Simon M","Olo Ndela E","Heyerhoff B","Freese HM","Poehlein A"],"additional_accession":[]},"is_claimable":false,"name":"New <i>Microviridae</i> isolated from <i>Sulfitobacter</i> reveals two cosmopolitan subfamilies of single-stranded DNA phages infecting marine and terrestrial Alphaproteobacteria.","description":"The <i>Microviridae</i> family represents one of the major clades of single-stranded DNA (ssDNA) phages. Their cultivated members are lytic and infect Proteobacteria, Bacteroidetes, and Chlamydiae. Prophages have been predicted in the genomes from Bacteroidales, Hyphomicrobiales, and Enterobacteriaceae and cluster within the 'Alpavirinae', 'Amoyvirinae', and <i>Gokushovirinae</i>. We have isolated 'Ascunsovirus oldenburgi' ICBM5, a novel phage distantly related to known <i>Microviridae</i>. It infects <i>Sulfitobacter dubius</i> SH24-1b and uses both a lytic and a carrier-state life strategy. Using ICBM5 proteins as a query, we uncovered in publicly available resources sixty-five new <i>Microviridae</i> prophages and episomes in bacterial genomes and retrieved forty-seven environmental vir","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T11:25:11.191Z","creation":"2025-04-07T03:47:24.491Z"},"accession":"S-EPMC9753089","cross_references":{"pubmed":["36533142"],"doi":["10.1093/ve/veac070"]}}