biostudies-literatureVeenstra MJDutch Research Council (NWO)13895-13898https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753097biostudies-literatureUnknown58(100)We present our design of a cross-catalytic system based on organocatalysis. The system features two organic reactions, namely a deprotection reaction of Fmoc protected proline and a Mannich reaction between acetone and dihydroisoquinoline. The products of these two reactions, proline and a tetrahydroisoquinoline, respectively, are capable of reciprocal reaction rate enhancement. Detailed kinetic studies of the system and seeding experiments support the cross-catalytic relationship in the reaction network.Chemical communications (Cambridge, England)Organocatalyst based cross-catalytic system.PMC9753097Gravity program 024.001.035Harutyunyan SRVeenstra MJfalseOrganocatalyst based cross-catalytic system.We present our design of a cross-catalytic system based on organocatalysis. The system features two organic reactions, namely a deprotection reaction of Fmoc protected proline and a Mannich reaction between acetone and dihydroisoquinoline. The products of these two reactions, proline and a tetrahydroisoquinoline, respectively, are capable of reciprocal reaction rate enhancement. Detailed kinetic studies of the system and seeding experiments support the cross-catalytic relationship in the reaction network.2022-01-01T00:00:00Z2022 Dec2025-04-18T16:30:46.292Z2025-04-07T03:46:16.646ZS-EPMC97530973644864410.1039/d2cc05610k