{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Z"],"funding":["NCI NIH HHS","NIGMS NIH HHS"],"pagination":["173"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753273"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Background</h4>There is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation and activation. However, there has been limited coordinated investigation of common epigenetic pathways among cell lineages. Further, it remains unclear if long-lived memory cell subtypes differentiate distinctly by cell lineages.<h4>Results</h4>We used the Illumina EPIC array to investigate the consistency of DNA methylation in B cell, CD4 T, and CD8 T naïve and memory cells states. In the process of naïve to memory activation across the three lineages, we identify considerable shared epigenetic regulation at the DNA level for immune memory generation. Further, in central to effector memory differentiation, our analyses revealed speci"],"journal":["Clinical epigenetics"],"pubmed_title":["Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages."],"pmcid":["PMC9753273"],"funding_grant_id":["P50 CA097257","R01 CA216265","P20 GM104416","R01 CA207360","P20 GM130423","R01 CA253976","P30 CA168524"],"pubmed_authors":["Butler R","Salas LA","Wiencke JK","Molinaro AM","Zhang Z","Bell-Glenn S","Koestler DC","Christensen BC","Warrier G","Kelsey KT"],"additional_accession":[]},"is_claimable":false,"name":"Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages.","description":"<h4>Background</h4>There is considerable evidence that epigenetic mechanisms and DNA methylation are critical drivers of immune cell lineage differentiation and activation. However, there has been limited coordinated investigation of common epigenetic pathways among cell lineages. Further, it remains unclear if long-lived memory cell subtypes differentiate distinctly by cell lineages.<h4>Results</h4>We used the Illumina EPIC array to investigate the consistency of DNA methylation in B cell, CD4 T, and CD8 T naïve and memory cells states. In the process of naïve to memory activation across the three lineages, we identify considerable shared epigenetic regulation at the DNA level for immune memory generation. Further, in central to effector memory differentiation, our analyses revealed speci","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-18T22:30:50.786Z","creation":"2025-04-07T10:13:48.725Z"},"accession":"S-EPMC9753273","cross_references":{"pubmed":["36522672"],"doi":["10.1186/s13148-022-01399-0"]}}