biostudies-literaturePei TNational Natural Science Foundation of ChinaNatural Science Foundation of Guangdong Province6066-6078https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753468biostudies-literatureUnknown26(24)Chronic kidney disease (CKD) affects approximately 10% of the global population. Muscle atrophy occurs in patients with almost all types of CKD, and the gut microbiome is closely related to protein consumption during chronic renal failure (CRF). This study investigated the effects of Bacteroides plebeius on protein energy consumption in rats with CKD, and our results suggest that Bacteroides plebeius may combat muscle atrophy through the Mystn/ActRIIB/SMAD2 pathway. A total of 5/6 Nx rats were used as a model of muscle wasting in CKD. The rats with muscle wasting were administered Bacteroides plebeius (2 × 10⁸  cfu/0.2 ml) for 8 weeks. The results showed that Bacteroides plebeius administration significantly inhibited muscle wasting in CKD. High-throughput 16 S rRNA pyrosequenciJournal of cellular and molecular medicineBacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut-renal muscle axis.PMC975346881673890820043362017A0303137508197380482174322817740352022A1515011405Zhang JHe JWang FXiao WMa YYan SHan ZYan YZhu DWang MJu LHe ZYang SHu RPei TfalseBacteroides plebeius improves muscle wasting in chronic kidney disease by modulating the gut-renal muscle axis.Chronic kidney disease (CKD) affects approximately 10% of the global population. Muscle atrophy occurs in patients with almost all types of CKD, and the gut microbiome is closely related to protein consumption during chronic renal failure (CRF). This study investigated the effects of Bacteroides plebeius on protein energy consumption in rats with CKD, and our results suggest that Bacteroides plebeius may combat muscle atrophy through the Mystn/ActRIIB/SMAD2 pathway. A total of 5/6 Nx rats were used as a model of muscle wasting in CKD. The rats with muscle wasting were administered Bacteroides plebeius (2 × 10⁸  cfu/0.2 ml) for 8 weeks. The results showed that Bacteroides plebeius administration significantly inhibited muscle wasting in CKD. High-throughput 16 S rRNA pyrosequenci2022-01-01T00:00:00Z2022 Dec2025-04-04T19:49:54.06Z2025-04-04T19:49:54.06ZS-EPMC97534683645853710.1111/jcmm.17626