{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Saw EL"],"pubmed_abstract":["<h4>Background</h4>Skeletal muscle (SkM) phenotypic switching is associated with exercise intolerance in heart failure with preserved ejection fraction (HFpEF). Patients with HFpEF have decreased type-1 oxidative fibers and mitochondrial dysfunction, indicative of impaired oxidative capacity. The <i>SAUNA</i> (SAlty drinking water/Unilateral Nephrectomy/Aldosterone) mice are commonly used in HFpEF pre-clinical studies and demonstrate cardiac, lung, kidney, and white adipose tissue impairments. However, the SkM (specifically the oxidative-predominant, <i>soleus</i> muscle) has not been described in this preclinical HFpEF model. We sought to characterize the <i>soleus</i> skeletal muscle in the HFpEF <i>SAUNA</i> mice and investigate its translational potential.<h4>Methods</h4>HFpEF was indu"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["1016452"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753550"],"repository":["biostudies-literature"],"pubmed_title":["Skeletal muscle phenotypic switching in heart failure with preserved ejection fraction."],"pmcid":["PMC9753550"],"pubmed_authors":["Valero-Munoz M","Saw EL","Werner LD","Zamani P","Sam F","Chirinos JA"],"additional_accession":[]},"is_claimable":false,"name":"Skeletal muscle phenotypic switching in heart failure with preserved ejection fraction.","description":"<h4>Background</h4>Skeletal muscle (SkM) phenotypic switching is associated with exercise intolerance in heart failure with preserved ejection fraction (HFpEF). Patients with HFpEF have decreased type-1 oxidative fibers and mitochondrial dysfunction, indicative of impaired oxidative capacity. The <i>SAUNA</i> (SAlty drinking water/Unilateral Nephrectomy/Aldosterone) mice are commonly used in HFpEF pre-clinical studies and demonstrate cardiac, lung, kidney, and white adipose tissue impairments. However, the SkM (specifically the oxidative-predominant, <i>soleus</i> muscle) has not been described in this preclinical HFpEF model. We sought to characterize the <i>soleus</i> skeletal muscle in the HFpEF <i>SAUNA</i> mice and investigate its translational potential.<h4>Methods</h4>HFpEF was indu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T16:31:22.59Z","creation":"2025-04-07T03:44:28.427Z"},"accession":"S-EPMC9753550","cross_references":{"pubmed":["36531739"],"doi":["10.3389/fcvm.2022.1016452"]}}