biostudies-literatureUnknown9Saw EL<h4>Background</h4>Skeletal muscle (SkM) phenotypic switching is associated with exercise intolerance in heart failure with preserved ejection fraction (HFpEF). Patients with HFpEF have decreased type-1 oxidative fibers and mitochondrial dysfunction, indicative of impaired oxidative capacity. The <i>SAUNA</i> (SAlty drinking water/Unilateral Nephrectomy/Aldosterone) mice are commonly used in HFpEF pre-clinical studies and demonstrate cardiac, lung, kidney, and white adipose tissue impairments. However, the SkM (specifically the oxidative-predominant, <i>soleus</i> muscle) has not been described in this preclinical HFpEF model. We sought to characterize the <i>soleus</i> skeletal muscle in the HFpEF <i>SAUNA</i> mice and investigate its translational potential.<h4>Methods</h4>HFpEF was induFrontiers in cardiovascular medicine1016452https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753550biostudies-literatureSkeletal muscle phenotypic switching in heart failure with preserved ejection fraction.PMC9753550Valero-Munoz MSaw ELWerner LDZamani PSam FChirinos JAfalseSkeletal muscle phenotypic switching in heart failure with preserved ejection fraction.<h4>Background</h4>Skeletal muscle (SkM) phenotypic switching is associated with exercise intolerance in heart failure with preserved ejection fraction (HFpEF). Patients with HFpEF have decreased type-1 oxidative fibers and mitochondrial dysfunction, indicative of impaired oxidative capacity. The <i>SAUNA</i> (SAlty drinking water/Unilateral Nephrectomy/Aldosterone) mice are commonly used in HFpEF pre-clinical studies and demonstrate cardiac, lung, kidney, and white adipose tissue impairments. However, the SkM (specifically the oxidative-predominant, <i>soleus</i> muscle) has not been described in this preclinical HFpEF model. We sought to characterize the <i>soleus</i> skeletal muscle in the HFpEF <i>SAUNA</i> mice and investigate its translational potential.<h4>Methods</h4>HFpEF was indu2022-01-01T00:00:00Z20222025-04-18T16:31:22.59Z2025-04-07T03:44:28.427ZS-EPMC97535503653173910.3389/fcvm.2022.1016452