{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hassan N"],"funding":["Cancer Research UK","Medical Research Council","Blood Cancer UK","National Institute for Health Research (NIHR)"],"pagination":["935949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<h4>Introduction</h4>NK cells play an important role in suppression of viral replication and are critical for effective control of persistent infections such as herpesviruses. Cytomegalovirus infection is associated with expansion of 'adaptive-memory' NK cells with a characteristic CD56dimCD16bright NKG2C+ phenotype but the mechanisms by which this population is maintained remain uncertain.<h4>Methods</h4>We studied NK cell reconstitution in patients undergoing haemopoietic stem cell transplantation and related this to CMV reactivation.<h4>Results</h4>NK cells expanded in the early post-transplant period but then remained stable in the absence of viral reactivation. However, CMV reactivation led to a rapid and sustained 10-fold increase in NK cell number. The proportion of NKG2C-expressing"],"journal":["Frontiers in immunology"],"pubmed_title":["CMV reactivation initiates long-term expansion and differentiation of the NK cell repertoire."],"pmcid":["PMC9753568"],"funding_grant_id":["29430","12052","CL-2015-09-001","NF-SI-0617-10163","MR/R011230/1"],"pubmed_authors":["Hassan N","Kinsella F","Eldershaw S","Zuo J","Moss P","Craddock C","Stephens C","Malladi R"],"additional_accession":[]},"is_claimable":false,"name":"CMV reactivation initiates long-term expansion and differentiation of the NK cell repertoire.","description":"<h4>Introduction</h4>NK cells play an important role in suppression of viral replication and are critical for effective control of persistent infections such as herpesviruses. Cytomegalovirus infection is associated with expansion of 'adaptive-memory' NK cells with a characteristic CD56dimCD16bright NKG2C+ phenotype but the mechanisms by which this population is maintained remain uncertain.<h4>Methods</h4>We studied NK cell reconstitution in patients undergoing haemopoietic stem cell transplantation and related this to CMV reactivation.<h4>Results</h4>NK cells expanded in the early post-transplant period but then remained stable in the absence of viral reactivation. However, CMV reactivation led to a rapid and sustained 10-fold increase in NK cell number. The proportion of NKG2C-expressing","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T16:04:00.378Z","creation":"2025-04-04T19:49:31.834Z"},"accession":"S-EPMC9753568","cross_references":{"pubmed":["36531994"],"doi":["10.3389/fimmu.2022.935949"]}}