{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi W"],"funding":["Swiss National Science Foundation","Multidisciplinary University Research Initiative","National Institutes of Health","National Science Foundation"],"pagination":["653-657"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753762"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(3)"],"pubmed_abstract":["Polymeric nanoscale materials able to target and accumulate in the tumor microenvironment (TME) offer promising routes for a safer delivery of anticancer drugs. By reaching their targets before significant amounts of drug are released, such materials can reduce off-target side effects and maximize drug concentration in the TME. However, poor drug loading capacity and inefficient nanomaterial penetration into the tumor can limit their therapeutic efficacy. Herein, we provide a novel approach to achieve high loading profiles while ensuring fast and efficient drug penetration in the tumor. This is achieved by co-polymerizing light-sensitive paclitaxel with monomers responsive to tumor-associated enzymes, and assembling the resulting di-block copolymers into spherical micelles. While light exposure enables paclitaxel to decouple from the polymeric backbone into light-activated micelles, enzymatic digestion in the TME initiates its burst release. Through a series of in vitro cytotoxicity assays, we demonstrate that these light-switch micelles hold greater potency than covalently linked, non-triggered micelles, and enable therapeutic profiles comparable to that of the free drug."],"journal":["Biomaterials science"],"pubmed_title":["High efficiency loading of micellar nanoparticles with a light switch for enzyme-induced rapid release of cargo."],"pmcid":["PMC9753762"],"funding_grant_id":["R01HL139001","DMR-1710105","W911NF15-1-0568"],"pubmed_authors":["Gianneschi NC","Battistella C","Choi W"],"additional_accession":[]},"is_claimable":false,"name":"High efficiency loading of micellar nanoparticles with a light switch for enzyme-induced rapid release of cargo.","description":"Polymeric nanoscale materials able to target and accumulate in the tumor microenvironment (TME) offer promising routes for a safer delivery of anticancer drugs. By reaching their targets before significant amounts of drug are released, such materials can reduce off-target side effects and maximize drug concentration in the TME. However, poor drug loading capacity and inefficient nanomaterial penetration into the tumor can limit their therapeutic efficacy. Herein, we provide a novel approach to achieve high loading profiles while ensuring fast and efficient drug penetration in the tumor. This is achieved by co-polymerizing light-sensitive paclitaxel with monomers responsive to tumor-associated enzymes, and assembling the resulting di-block copolymers into spherical micelles. While light exposure enables paclitaxel to decouple from the polymeric backbone into light-activated micelles, enzymatic digestion in the TME initiates its burst release. Through a series of in vitro cytotoxicity assays, we demonstrate that these light-switch micelles hold greater potency than covalently linked, non-triggered micelles, and enable therapeutic profiles comparable to that of the free drug.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2025-04-04T19:11:15.957Z","creation":"2025-04-04T19:11:15.957Z"},"accession":"S-EPMC9753762","cross_references":{"pubmed":["33300507"],"doi":["10.1039/d0bm01713b"]}}