{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jang JY"],"funding":["Forkhead BioTherapeutics","NCI/NIH","NCI NIH HHS","National Research Foundation of Korea","Leukemia and Lymphoma Society"],"pagination":["e160767"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9753996"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["132(24)"],"pubmed_abstract":["Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of mantle cell lymphoma (MCL), we identified a set of transcription factors (TFs) including FOXO1, EBF1, PAX5, and IRF4 that are essential for MCL propagation. Integrated chromatin immunoprecipitation and sequencing (ChIP-Seq) with transcriptional network reconstruction analysis revealed FOXO1 as a master regulator that acts upstream in the regulatory TF hierarchy. FOXO1 is both necessary and sufficient to drive MCL lineage commitment through supporting the lineage-specific transcription programs. We further show that FOXO1, but not its close paralog FOXO3, can reprogram myeloid leukemia cells and induce B-lineage gene "],"journal":["The Journal of clinical investigation"],"pubmed_title":["A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas."],"pmcid":["PMC9753996"],"funding_grant_id":["201077","P30 CA016058","MCL7001–18","2021R1A6A3A03039136","P01 CA214274","CA214274"],"pubmed_authors":["Yao J","Elemento O","Kluk MJ","Belvedere S","Baiocchi RA","Jang JY","Hwang I","Di Liberto M","Pan H","Zanettini C","Imada E","Zheng H","Chen Z","Ballman KV","Paik J","Lin HV","Huang X","Cantley LC","Chen-Kiang S","Marchionni L","Alinari L","Lee Y","Wang Y","Inghirami G"],"additional_accession":[]},"is_claimable":false,"name":"A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.","description":"Targeting lineage-defined transcriptional dependencies has emerged as an effective therapeutic strategy in cancer treatment. Through screening for molecular vulnerabilities of mantle cell lymphoma (MCL), we identified a set of transcription factors (TFs) including FOXO1, EBF1, PAX5, and IRF4 that are essential for MCL propagation. Integrated chromatin immunoprecipitation and sequencing (ChIP-Seq) with transcriptional network reconstruction analysis revealed FOXO1 as a master regulator that acts upstream in the regulatory TF hierarchy. FOXO1 is both necessary and sufficient to drive MCL lineage commitment through supporting the lineage-specific transcription programs. We further show that FOXO1, but not its close paralog FOXO3, can reprogram myeloid leukemia cells and induce B-lineage gene ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-29T18:57:57.964Z","creation":"2025-04-19T22:45:43.484Z"},"accession":"S-EPMC9753996","cross_references":{"pubmed":["36282572"],"doi":["10.1172/JCI160767"]}}