biostudies-literaturePierce RWNHLBI NIH HHSS97-S102https://www.ebi.ac.uk/biostudies/studies/S-EPMC9754809biostudies-literatureUnknown149(1 Suppl 1)<h4>Objectives</h4>To review, analyze, and synthesize the literature on endothelial dysfunction in critically ill children with multiple organ dysfunction syndrome and to develop a consensus biomarker-based definition and diagnostic criteria.<h4>Data sources</h4>Electronic searches of PubMed and Embase were conducted from January 1992 to January 2020, using a combination of medical subject heading terms and key words to define concepts of endothelial dysfunction, pediatric critical illness, and outcomes.<h4>Study selection</h4>Studies were included if they evaluated critically ill children with endothelial dysfunction, evaluated performance characteristics of assessment/scoring tools to screen for endothelial dysfunction, and assessed outcomes related to mortality, functional status, organPediatricsEndothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.PMC9754809L30 HL149099Leteurtre SPediatric Organ Dysfunction Information Update Mandate (PODIUM) CollaborativeJeffries HDoctor AOuellette YRobinson KAGorga SMTyppo KVPathan NTissieres PBembea MMMuszynski JAWillson DCholette JWynn JLWainwright MSAkcan-Arikan ALee JHParker RHall MTucci MHassinger ABIrving SYFarris RWDYehya NJouvet PWatson RSSmith LSCheifetz IMSanchez-Pinto LNFaustino EVSFitzgerald JCPrince JMCarcillo JAWhitney JELeclerc FGiuliano JSPierce RWThiagarajan RLacroix JSelewski DTPineda JAlexander PBrown AMOdetola FRowan CMHanson SJThomas NMcKiernan PJEckerle MCornell TMenon KWeiss SAgus MSrinivasan VGaies MSchekerdemian LSBasu RBennett TDSquires RHGuilliams KLobner KLaussen PRyerson LMSquires JEWard SLBrandao LRSutherland SMErickson SSpaeder MCKhemani RGSteiner MEChecchia PFuhrman DYMonagle PTasker RCZimmerman JJKannan STraube CSchlapbach LJKaram OBohn DHartman MKissoon NSimon DfalseEndothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference.<h4>Objectives</h4>To review, analyze, and synthesize the literature on endothelial dysfunction in critically ill children with multiple organ dysfunction syndrome and to develop a consensus biomarker-based definition and diagnostic criteria.<h4>Data sources</h4>Electronic searches of PubMed and Embase were conducted from January 1992 to January 2020, using a combination of medical subject heading terms and key words to define concepts of endothelial dysfunction, pediatric critical illness, and outcomes.<h4>Study selection</h4>Studies were included if they evaluated critically ill children with endothelial dysfunction, evaluated performance characteristics of assessment/scoring tools to screen for endothelial dysfunction, and assessed outcomes related to mortality, functional status, organ2022-01-01T00:00:00Z2022 Jan2025-05-29T16:30:16.188Z2025-05-29T16:30:16.188ZS-EPMC97548093497067610.1542/peds.2021-052888O10.1542/peds.2021-052888o