biostudies-literatureUnknown9Fineschi M<h4>Background</h4>In ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary angioplasty (PPCI) the index of microcirculatory resistance (IMR) correlates to the extent of myocardial damage and left ventricular (LV) function recovery. Data on the IMR time-course and impact on clinical outcome in STEMI patients with multi-vessel disease (MVD) are scarce.<h4>Aims</h4>We designed a prospective, multicenter clinical trial to assess the infarct-related artery (IRA)-IMR in STEMI patients with MVD undergoing PPCI and to explore its potential in relationship with outcome and LV remodeling.<h4>Methods</h4>The study enrolled 242 STEMI patients with MVD. Both fractional flow reserve (FFR) and IMR of the IRA were assessed after successful PPCI. Then, FFR/IMR measurFrontiers in cardiovascular medicine1051174https://www.ebi.ac.uk/biostudies/studies/S-EPMC9755670biostudies-literatureOne-year results from the Assessing MICRO-vascular resistances <i>via</i> IMR to predict outcome in ST-elevation myocardial infarction patients with multivessel disease undergoing primary PCI (AMICRO) trial.PMC9755670Verna EMezzapelle GFineschi MRepetto AManari ALucarelli KTuriano GGuiducci VUguccioni LTarantini GBarioli ABartolini DfalseOne-year results from the Assessing MICRO-vascular resistances <i>via</i> IMR to predict outcome in ST-elevation myocardial infarction patients with multivessel disease undergoing primary PCI (AMICRO) trial.<h4>Background</h4>In ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary angioplasty (PPCI) the index of microcirculatory resistance (IMR) correlates to the extent of myocardial damage and left ventricular (LV) function recovery. Data on the IMR time-course and impact on clinical outcome in STEMI patients with multi-vessel disease (MVD) are scarce.<h4>Aims</h4>We designed a prospective, multicenter clinical trial to assess the infarct-related artery (IRA)-IMR in STEMI patients with MVD undergoing PPCI and to explore its potential in relationship with outcome and LV remodeling.<h4>Methods</h4>The study enrolled 242 STEMI patients with MVD. Both fractional flow reserve (FFR) and IMR of the IRA were assessed after successful PPCI. Then, FFR/IMR measur2022-01-01T00:00:00Z20222026-06-21T03:17:32.656Z2025-05-29T20:21:22.264ZS-EPMC97556703653173610.3389/fcvm.2022.1051174