{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["An N"],"pubmed_abstract":["<h4>Background</h4>Type I interferon (IFN) inhibits virus infection through multiple processes. Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the cellular metabolism. The sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1), as an interferon-stimulated gene (ISG), has been reported to inhibit a number of retroviruses and DNA viruses, by depleting dNTPs indispensable for viral DNA replication. Here we report a new antiviral activity of SAMHD1 against RNA viruses including HCV and some other flaviviruses infection.<h4>Methods</h4>Multiple cellular and molecular biological technologies have been used to detect virus infection, replication and variation of intracellular proteins, including western blotting, qRT-PCR, Gen"],"journal":["Frontiers in immunology"],"pagination":["1007718"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9755837"],"repository":["biostudies-literature"],"pubmed_title":["Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis."],"pmcid":["PMC9755837"],"pubmed_authors":["Liang C","Cen S","Li X","Shao H","An N","Yang L","Guo F","Li Q","Ge Q","Yi D"],"additional_accession":[]},"is_claimable":false,"name":"Interferon-inducible SAMHD1 restricts viral replication through downregulation of lipid synthesis.","description":"<h4>Background</h4>Type I interferon (IFN) inhibits virus infection through multiple processes. Recent evidence indicates that IFN carries out its antiviral activity through readjusting of the cellular metabolism. The sterile alpha motif and histidine-aspartate domain containing protein 1 (SAMHD1), as an interferon-stimulated gene (ISG), has been reported to inhibit a number of retroviruses and DNA viruses, by depleting dNTPs indispensable for viral DNA replication. Here we report a new antiviral activity of SAMHD1 against RNA viruses including HCV and some other flaviviruses infection.<h4>Methods</h4>Multiple cellular and molecular biological technologies have been used to detect virus infection, replication and variation of intracellular proteins, including western blotting, qRT-PCR, Gen","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-30T03:12:32.122Z","creation":"2025-04-06T23:01:33.708Z"},"accession":"S-EPMC9755837","cross_references":{"pubmed":["36532074"],"doi":["10.3389/fimmu.2022.1007718"]}}